Alzheimer's disease (AD), the most common form of dementia, is an age-related neurodegenerative disease that is characterized by memory dysfunction, neuronal cell damage, and neuroinflammation. It is believed that AD-related pathology is mostly due to the overproduction of Aβ, especially the oligomeric form (AβO), in the brain. Evidence of the effects of multifunctional medicinal herbs in the t...

Abstract Macroscale cleavage fracture toughness of high strength steels is strongly related to the hard microstructural inclusions. Therefore, an accurate determination local stress on these inclusions based matrix necessary for statistical modelling macroscale fracture. This paper presents analytical equations quantitatively estimate from far-field matrix. The account inclusion shape, orientat...

We present query execution strategies that are optimized for the characteristics of tertiary memory devices. Traditional query execution methods are oriented to magnetic disk or main memory and perform poorly on tertiary memory. Our methods use ordering and batching techniques on the I/O requests to reduce the media switch cost and seek cost on these devices. Some of our methods are provably op...

We consider the problem of computing Skolem functions for satisfied dependency quantified Boolean formulas (DQBFs). We show how Skolem functions can be obtained from an elimination-based DQBF solver and how to take preprocessing steps into account. The size of the Skolem functions is optimized by don’t-care minimization using Craig interpolants and rewriting techniques. Experiments with our DQB...

The Alberta Stroke Program Early CT score (ASPECTS) scoring method is frequently used for quantifying early ischemic changes (EICs) in patients with acute ischemic stroke in clinical studies. Varying interobserver agreement has been reported, however, with limited agreement. Therefore, our goal was to develop and evaluate an automated brain densitometric method. It divides CT scans of the brain...

Multi-layered systems used in automotive plain bearings show complex patterns of crack growth under service conditions. The studied architecture consists of a steel backing (1.8 mm), a compliant pure-aluminum interlayer (0.04 mm) and a lining of medium-strength aluminum alloy (0.38 mm). Previous experimental studies [1] with flat strip specimens of identical architecture under three point bendi...

Article history: Received 12 November 2014 Received in revised form 26 December 2014 Accepted 29 January 2015 Available online 10 February 2015