a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

Abstract This work addresses the design of miniature compliant displacement amplifiers. The optimum mechanism is generated through topology optimization two-node frame elements with linearly varying cross sections using Ant Colony Optimization technique. First, stiffness matrices that account for change in cross-section dimensions are formulated. Then, each element assigned 5 independent ants r...

Combinatorial optimization problems (COPs) arise in many practical applications in the fields of management science, biology, chemistry, physics, engineering, and computer science. Although the search space is comprised of a finite number of candidate solutions, many of these problems are very complex and thus hard to solve. Often, the search space grows exponentially with the problem size rend...

The optimum analytical Conditions with regard to two or more variables can be determined in an unambiguous way by use of the simplex method. The method is particularly applicable to problems involving interacting variables. We describe the application of the simplex technique to the optimization of two procedures on a continuous-flow analyzer (AutoAnalyzer) and to the optimization of chemical v...