AIMS/INTRODUCTION The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel is a key component of insulin secretion in pancreatic β-cells. Activating mutations in ABCC8 encoding for the sulfonylurea receptor subunit of the KATP channel have been associated with the development of neonatal diabetes mellitus (NDM). The aim was to investigate clinical and functional characterization of t...

The regeneration of a new oral apparatus in Stentor coeruleus (oral regeneration) has been shown to be sensitive to events that inhibit calcium uptake and calmodulin function. Removal of extracellular calcium delays oral regeneration significantly. The calcium channel antagonist verapamil also delays oral regeneration, as does lanthanum, which is known to block calcium uptake. Both inhibitors a...

Objective: Azelnidipine, a long-acting dihydropyridine based calcium channel blocker, on oral administration, the drug undergoes extensive first pass metabolism. Delivery of azelnidipine (AZP) via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, is to investigate the development and ev...

The three most common classes of medications implicated in drug-induced gum enlargement are anticonvulsives, calcineurin inhibitors, and calcium channel blockers. Treatment primarily consists of withdrawing the offending agent whenever possible, in addition to maintaining good oral hygiene. Gingivectomy or flap surgery may be needed in resistant cases.

AIMS To determine whether systemic hypertension and glaucoma might coexist more often than expected, with possible implications for treatment. METHODS Case-control study using general practitioner database of patients with glaucoma matched with controls for age and sex. RESULTS Hypertension was significantly more common in the 27,080 patients with glaucoma (odds ratio 1.29, 95% confidence i...

We have investigated the interaction of clotrimazole (CLT) and related compounds with the erythroid Ca2"-activated K+ channel, a mediator of sickle cell dehydration. We measured K+ transport, membrane potential, and cell volume upon activation of this pathway in sickle erythrocytes. CLT blocked almost completely Ca2"-activated K+ transport in homozygous hemoglobin S cells, with IC5o values of 2...

The potential utility of Ca2+ channel blockers in the treatment of various psychiatric disorders has been recently suggested. In the present study, the behavioural and anti-psychotic effects of Ca2+ channel blockers were investigated in unrestrained rhesus monkeys (Macaca mulatta) living together in a colony. The different behaviours categorised as social, solitary and abnormal were video recor...

OBJECTIVE ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells are crucial in the regulation of glucose-induced insulin secretion. Recently, K(ATP) channel-deficient mice were generated by genetic disruption of Kir6.2, the pore-forming component of K(ATP) channels, but the mice still showed a significant insulin response after oral glucose loading in vivo. Gastric inhibitory polypeptid...