The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with no...

The American Diabetes Association has strongly recommended that fasting plasma glucose should be sufficient for establishing diagnosis of diabetes mellitus; while World Health Organization supports to maintain the oral glucose tolerance test. Several epidemiological studies confirmed that postprandial hyperglycemia is a significant predictor for cardiovascular mortality and incidence. Post-chal...

The availability of quantitative indexes describing beta-cell function in normal life conditions is important for the characterization of impaired mechanisms of insulin secretion in pathophysiological states. Recently, an oral C-peptide minimal model has been proposed and applied to subjects with normal glucose tolerance (NGT) during graded up-and-down glucose infusion protocols (40-min periods...

Muscle mass inversely relates to 2 hours glucose levels after oral glucose load in non-diabetic subjects. A study in glucose intolerance subjects has never been performed. We conducted this study to determine the relationship between muscle mass and glucose level after oral glucose load in glucose intolerance subjects. Sixty Thai subjects, 44 drug-naïve, newly diagnosed type 2 diabetes mellitus...

The hepatoportal area is an important glucohomeostatic metabolic sensor, sensing hypoglycemia, hyperglycemia, and hormones such as glucagon-like peptide-1 (GLP-1). We have reported previously that activation of hepatoportal sensors by intraportal infusion of glucose and GLP-1 or by subcutaneous administration of GLP-1 receptor activator exenatide and of intraportal glucose improved glycemia ind...

Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1), cholecystokinin and insulin; slows gastric emptying (GE); lowers post-meal glucose men. Oral sensitivity to bitter substances may be greater women than We, accordingly, evaluated dose-related effects quinine on GE, glycaemic responses to, a mixed-nutrient drink females, compared higher with those males. A ...

background and objective: lowering serum glucose and lipid levels in diabetic patients by using natural materials is of great importance. in this study, the effect of oral consumption of fumaria parviflora lamwas was assessed on serum glucose and lipid levels in streptozocin diabetic rats. materials and methods: in this experimental study, 32 male wistar rats were divided into four groups of co...

in the present study, under typical management conditions of dairy farms in iran, the effect of oral administration of on serum glucose, ast and arginase(indices of liver injuries) of oral monensin was assessed. thirteen multiparous holstein cows were blocked into a control and an experiment group from 3 weeks prepartum to 45 days postpartum according the number of their calvings. the groups re...