The oral glucose tolerance test (OGTT) is the recommended diagnostic test for gestational diabetes mellitus (GDM). There is no consensus regarding the diagnostic criteria and OGTTs described by the World Health Organization (WHO) [1] and the American Diabetes Association [2] are the tests most frequently used. In 1999, the WHO changed the threshold values for the 75g OGTT to a fasting venous pl...

Introduction Impaired glucose tolerance (IGT) is diagnosed by a standardized oral glucose tolerance test (OGTT). However, the OGTT is laborious, and when not performed, glucose tolerance cannot be determined from fasting samples retrospectively. We tested if glucose tolerance status is reasonably predictable from a combination of demographic, anthropometric, and laboratory data assessed at one ...

INTRODUCTION AND OBJECTIVES Traditionally, the oral glucose tolerance test has been useful to diagnose unknown diabetes. Recently, the American Diabetes Association committee has accepted glycated hemoglobin ≥ 6.5% as a criterion for unknown diabetes. The aim was to determine the benefit of glycated hemoglobin for diagnosing unknown diabetes and also create a predictive model that adjusts the i...

CONTEXT Cirrhosis, diabetes mellitus, impaired glucose tolerance, insulin resistance, and protein calorie malnutrition are important issues in cirrhotic patients because they can increase the progression of liver disease and worsen its prognosis. OBJECTIVE To determine the prevalence of diabetes mellitus, impaired glucose tolerance and insulin resistance in cirrhotic patients being evaluated ...

We investigated the relationship between glucose tolerance and birth weight in a group of 7-year-old black South Africans on whom longitudinal anthropometric data were available. Oral glucose tolerance tests (OGTT’s) were carried out on 152 subjects and inverse correlations were found between birth weight and the total amount of insulin secreted during the first 30 minutes (r= -0.19, p=0.04) an...

Type 2 diabetes mellitus (T2DM) is characterized by a progressive failure of pancreatic β-cell function (BCF) with insulin resistance. Once insulin over-secretion can no longer compensate for the degree of insulin resistance, hyperglycemia becomes clinically significant and deterioration of residual β-cell reserve accelerates. This pathophysiology has important therapeutic implications. Ideally...

Hyperglycemia is an important independent risk factor in the development of coronary artery disease. Sixty one patients suffering from chronic and acute myocardial infarction out of which 12 patients were diabetic and 10 normal control subjects were investigated. The patients without diabetes and control subjects were subjected to oral and intravenous glucose tolerance tests. It was observed th...

Fernandes, J., Koster, J. F., Grose, W. F. A., and Sorgedrager, N. (1974). Archives of Disease in Childhood, 49, 186. Hepatic phosphorylase deficiency: its differentiation from other hepatic glycogenoses. Two brothers with glycogen storage disease of the liver are reported. The clinical symptoms were hepatomegaly and a slight muscle hypotonia; hypoglycaemic symptoms seldom occurred. There was d...

BACKGROUND The Canadian and American Diabetes Associations recommend the use of an oral glucose tolerance test to screen for abnormal glucose tolerance among women with polycystic ovary syndrome when their fasting plasma glucose level is 5.7 mmol/L or more (Canadian guideline) and 5.6 mmol/L or more (American). Our objective was to determine the predictive value of 5.6 mmol/L as a fasting plasm...

BACKGROUND Calcineurin-inhibitors and hepatitis C virus (HCV) infection increase the risk of post-transplant diabetes mellitus. Chronic HCV infection promotes insulin resistance rather than beta-cell dysfunction. The objective was to elucidate whether a conversion from tacrolimus to cyclosporine A affects fasting and/or dynamic insulin sensitivity, insulin secretion or all in HCV-positive renal...