Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa whose etiology is still unknown but mounting evidence points to the immunologic basis of this disorder [1]. OLP has many different forms; however, reticular type is the most frequent one. OLP is thought to be precancerous lesion with different percentages of malignant transformation reported in the literature. It is wel...

In their recent publication, Garcia-Pola et al. (1) (2016) suggested the development of proliferative verrucous leukoplakia (PVL) in oral lichen planus (OLP). It was described as a preliminary study, where this association supposedly occurred. They presented a retrospective analysis with a long-term follow-up, showing an interesting relationship between these lesions. It is important to emphasi...

This article is a systematic review to evaluate the role of LASER in treatment LP and OLP. These two are potentially malignant disorder with high prevalence rate transformation. Many modality been stated for same but has attracted special attention properties it possess. : The aim this research was compare effectiveness (light amplification by stimulated emission radiation) on management leukop...

Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides oppo...

Oral lichen planus (OLP) is a chronic oral inflammatory disease of unknown etiology. According to reports, 1-2% of OLP patients develop oral squamous cell carcinoma (OSCC) in the long run. While World Health Organization (WHO) classifies OLP as "a potentially malignant disorder," it is still a matter of debate which mechanisms drive OLP to such a condition. The current hypothesis connecting OLP...

Oral lichen planus (OLP) is a chronic, multifocal, sometimes painful, inflammatory disease of the oral mucosa. OLP can predispose development of psycho-emotional disorders. Until now, the relationship between the severity of lichen planus and the psychological profile of patients (psychological well-being, perceived stress and pain coping strategies) has never been studied. Study was conducted ...

Background and Aim: Oral lichen planus (OLP) is a chronic inflammatory lesion. Psychological stress occurs when someone senses that environmental demands exceed his/her adaptive capability. Stress, anxiety, and depression have frequently been mentioned as possible factors related to the development of OLP, although this association remains controversial. In most studies, a positive correlation ...

background:   materials and methods: this was a cross-sectional study carried out among 70 samples, including 10 samples from normal healthy mucosa categorized into group 1, group 2 (30 olp), and group 3 (30 oed) samples. five sections (4 μm thick) were obtained and stained with monoclonal antibodies such as ki-67, p53, bcl-2, and bax and analyzed for number of positive cells and also for inten...

BACKGROUND Oral lichen planus (OLP) is a T cell mediated immune response. T cells locally present in the involved tissues release cytokines like interleukin-6 (IL-6), which contributes to pathogenesis of OLP. Also IL-6 has been associated with multidrug resistance protein (MRP) expression by keratinocytes. Correspondingly, upregulation of MRP was found in OLP. We conducted this study to evaluat...

  Background: Oral lichen planus (OLP) has been classified as a pre-malignant condition. Matrix metalloproteinase-13 (MMP-13) or collagenase-3 may play a key role in cancer development. The aim of this study was to compare serum and saliva MMP-13 between patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).   Methods : This cross sectional study was performed on 30 pat...