Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral cavity. The conventional tumour and several histologic subtypes of SCC present morphologic features and specific behaviour when they occur in the oral mucosa. For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biolo...

the primary carcinoma may secondarily invade bone tissue through direct extensions, blood circulation or lymphatic transportation particulary when it is arising from breast, prostate, kidney, thyroid and lung. metastatics tumors of bone are more common than primary tumor of bone. the most common tumor, which metastasizes into bone, is the breast adenocarcinoma. some metastatic tumors of bone in...

head and neck squamous cell carcinoma, including oral squamous cell carcinoma (oscc) is the sixth most common cancer in the human population. despite significant efforts committed in treatment of oscc the overall survival rate of oscc has not improved significantly. activating mutations in the fibroblast growth factor receptor 3 (fgfr3) genes are responsible for some human cancers, including bl...

Head and Neck Cancer (HNC) is a broad category of cancer, comprises cancer that origin into oral cavity, pharynx, larynx, sinuses salivary gland. Majority cases reported in Pakistan are metastatic to with morphology squamous cell carcinoma. Locally advance, un-resectable tumors treated systemic therapies. Commonly prescribe therapies includes chemotherapy targeted therapy. However, the most pre...

malignant tumors of the oral cavity which are metastatic are very rare and consist of 1% of malignancies of the oral cavity. numbness or paresthesia of the lower lip or the chin is the main feature of presence of metastasis in the jaw. our patient was a 38 year old woman with chief complaint of pain in the right half of her face, jaw and teeth. her medical history revealed a radical mastectomy ...

Osteosarcoma is relatively rare in the jaws and variable in presentation, thus its recognition may be quite confusing and delay diagnosis and treatment. Also, in contrast to most malignancies, osteosarcoma is usually encountered earlier in life and may clinically resemble features of more common oral entities such as chronic osteomyelitis, fibrous dysplasia, osteoblastic metastatic carcinom...

papillary thyroid carcinoma (ptc) is one of the most commonly diagnosed types of differentiated carcinoma of the thyroid. it is stated that lung is the most common site of metastasis followed by bone. the incidence of paranasal sinus (pns) metastasis is fairly uncommon in case of thyroid carcinoma. to the best of our knowledge, no case of metastatic ptc to nasal cavity has been reported. in thi...

Papillary thyroid carcinoma is the most common form of differentiated thyroid carcinoma. It is generally confined to the neck with or without spread to regional lymph nodes. Metastatic thyroid carcinomas are uncommon and mainly include lung and bone. Metastases involving oral and maxillofacial region are extremely rare. We described a case of malar metastasis revealing a follicular variant of p...

back ground: the aim of this study was to characterize the immunohistochemical expression of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma. materials and methods: immunohistochemical staining for galectins 1, 3, and 9 was evaluated in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41 samples of...

Introduction: Metastasis to the oral region from a malignant tumor elsewhere in the body is an uncommon but clinically important finding, because it may be the first indication that the patient has a distant primary tumor. Case report: A 65­year­old female presented with numb chin secondary to metastasis from thyroid follicular carcinoma is discussed. The lesion was located in the mandible on t...