OBJECTIVE Providing a safe and efficient dental treatment for a young patient is a challenge for the dentist and the child. The purpose of this study was to investigate the effectiveness, safety and acceptability of buccal midazolam in dental pediatric patients and to compare it with oral Midazolam. METHODS Eighteen uncooperative healthy children aged 2.5-6 years were randomized to each of bu...

This study aimed to describe the pharmacokinetics of midazolam and its cytochrome P450 3A (CYP3A) mediated metabolite 1-OH-midazolam in morbidly obese patients receiving oral and i.v. midazolam before (n = 20) and one year after weight loss surgery (n = 18), thereby providing insight into the influence of weight loss surgery on CYP3A activity in the gut wall and liver. In a semiphysiologically ...

BACKGROUND Preemptive analgesia is the blocking of pain perception afferent pathways before noxious painful stimuli. Clonidine is an alpha agonist drug that is partially selective for α-2 adrenoreceptors. Clonidine is used as anti-anxiety medication and an, analgesic, and it prolongs the duration of the block in the brachial plexus block. OBJECTIVES To compare the effect of preemptive clonidi...

background: investigation was designed to evaluate the behavioral changes in children receiving dental treatment while they have been administered combination of midazolam/ketamine or midazolam/promethazine. materials and methods: this was a randomized double blind clinical trial with cases being selected from those uncooperative children aged 2 to 6 years from those referred for treatment unde...

Much interest has been focused on the use of midazolam (Versed~Roche Laboratories of Hoffman LaRoche, Nutley, NJ) for conscious sedation in pediatric dentistry. The drug has been used as a preanesthetic sedative in adults and more recently in children. However, studies are lacking concerning its use in pediatric dentistry. The purpose of this paper is to review the pharmacokinetics of midazolam...

INTRODUCTION Both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations. Therefore, this study aimed to compare midazolam with midazolam-promethazine regarding induction, maintenance, and recovery characteristics following pediatric pr...

background sedation is a condition of reduced level of consciousness (loc) for a patient that is created to decrease irritability, anxiety, and restlessness. objectives in this study, we compared the sedative effect of oral administration of ketamine, midazolam, and atropine cocktail with diphenhydramine in the referent children to the emergency department. patients and methods based on the dou...

Background: To maintain immobility of children for good quality computed tomography (CT) scans, sedation may be used. Present study was planned to compare the efficacy oral triclofos and midazolam in undergoing CT. Methodology: The prospective, comparative, randomized Indian conducted Department Anaesthesia at a J.J. Hospital Grant Medical college. Study population paediatric subjects between 2...

Background: Midazolam and acetaminophen are often co-administered in anesthesia practice. Both are metabolized by CYP 3A4 enzyme in the liver, and hence compete for the enzyme sites. This might lead to reduced metabolic breakdown and enhanced pharmacodynamic effects of midazolam in the presence of acetaminophen. Methods: The present study was undertaken to test this hypothesis. After IRB approv...