OBJECTIVE To estimate the efficacy and safety of low-dose oral misoprostol compared with dinoprostone (PGE2), vaginal misoprostol, and oxytocin for labor induction in women with a viable fetus. DATA SOURCES We conducted electronic database searches of PubMed, MEDLINE, EMBASE, and the Cochrane Library for articles published before January 2008 using the keywords misoprostol, labor, induction, ...

Background: We sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus.Methods: This randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. Sublingual and vaginal tablets cont...

OBJECTIVES To compare the effectiveness and side effects of transvaginal application of 400 or 600 ug of misoprostol for termination of pregnancy. STUDY DESIGN A prospective randomized single-blinded trial. SETTING Department of Obstetrics & Gynecology, Bhumibol Adulyadej Hospital. MATERIAL AND METHOD One-hundred-and-twenty-five pregnant women with less than 20 weeks gestational, at Bhumi...

Given the overall safety profile and increasing availability of medical pregnancy termination drugs, we asked: would the mifepristone-misoprostol regimen for medical termination at ≤10 weeks of gestation meet US Food and Drug Administration regulatory criteria for over-the-counter (OTC) approval, and if not, what are the present research gaps? We conducted a literature review of consumer behavi...

Objective of this study was to achieve a safe vaginal delivery of patients with post datism by induction of labour. We sought to compare the efficacy and safety of oral misoprostol with vaginal misoprostol. 100 patients with post datism for induction of labour were divided into oral and vaginal group equally. Both the groups received 25mcg of misoprostol every 4 th hrly, either orally with wate...

OBJECTIVE Comparing the efficacy of low-dose sublingual misoprostol plus laminaria to medium-dose sublingual misoprostol alone for cervical dilation before surgical management of late first trimester missed abortions. METHODS Randomized, controlled trial evaluated 70 women with missed abortion, admitted for surgical termination of pregnancy. The patients were randomly assigned to receive 200 ...

Female lower abdominal pain poses diagnostic difficulties for clinicians, especially when little more than the history and physical examination are available. A girl presented with constant lower abdominal pain after taking misoprostol for pregnancy termination. She was eventually referred to a rural District Hospital, where a laparotomy demonstrated acute appendicitis. After treating herself f...