INTRODUCTION Lightning is the second most common storm-related cause of death. The mortality following lightning strike is 10% to 30% and a large proportion of these people suffer cardiopulmonary arrest at the time of the strike. Much less commonly, solid organ injuries occur from either primary or secondary blunt force trauma. CASE PRESENTATION To the best of our knowledge, this is the first...

In solid organ transplantation, ischemia/reperfusion (IR) injury during organ procurement, storage and reperfusion is an unavoidable detrimental event for the graft, as it amplifies graft inflammation and rejection. Intracellular mitogen-activated protein kinase (MAPK) signaling pathways regulate inflammation and cell survival during IR injury. The four best-characterized MAPK subfamilies are t...

Carbon monoxide (CO) may exert important roles in physiological and pathophysiological states through the regulation of cellular signaling pathways. CO can protect organ tissues from ischemia/reperfusion (I/R) injury by modulating intracellular redox status and by inhibiting inflammatory, apoptotic, and proliferative responses. However, the cellular mechanisms underlying the protective effects ...

BACKGROUND Therapeutic hypothermia is used to reduce ischemia/reperfusion injury (IRI) during organ transplantation and major surgery, but does not fully prevent organ injury. Interestingly, hibernating animals undergo repetitive periods of low body temperature called 'torpor' without signs of organ injury. Recently, we identified an essential role of hydrogen sulfide (H2S) in entrance into tor...

HYPOTHESIS Multiple organ dysfunction (MOD) within 48 hours of injury is a reversible physiologic response to tissue injury and resuscitation. DESIGN A prospective 10-year inception cohort study ending September 2003. SETTING Regional academic level I trauma center. PATIENTS One thousand two hundred seventy-seven consecutive trauma patients at risk for postinjury multiple organ failure (M...

background: sepsis related-multiple organ dysfunction is associated with ileum injury. we aimed to determine the causes of ileal injury in two models of microbial sepsis resulted from infection with aeromonas hydrophila or its endotoxin. we also evaluated the protective effect of phytic acid .   methods: thin sections of ileum from 60 swiss male mice in control, bacteria-infected or lipopolysac...

This review summarizes new insights in the pathophysiologic implications of inflammation and microvascular alterations in organ dysfunction, as well as genetic factor contribution, from clinical and experimental studies that were published in 2010 in Critical Care in the fields of multiple organ dysfunction and sepsis. New diagnostic and prognostic markers of organ dysfunction are presented. Ev...

The excellent results of vascularized organ transplantation have resulted in an increasing number of end-stage organ failure patients seeking such treatment. The results of organ transplantation depend on a number of factors--the quality of the donor (and an organ), living vs. deceased donation, magnitude of ischemic injury (and its prevention), and recipient-dependent factors. Ischemia/reperfu...

Sonography in trauma patients can be associated with obstacles as within obese patients or patients with intestinal gas. A retroperitoneal bleeding might be difficult to realize as there is no free fluid seen in the abdomen. Also, small hollow viscus organ lesions can easily be missed. A delay of the diagnose of a hollow viscus organ injury, such as a small bowl injury, has a major impact on th...

Cells are active components in their environment and constantly adjusting their performance to improve extracellular milieu changing. This approach is reflected their tends of maintaining intracellular homeostasis. When the cells encounter stress or pathologic stimuli, they can undergo a new manner (adaptation) and new steady state for achieving viability and function. If the external stress is...