OBJECTIVES To evaluate the sensitivity and specificity of ultrasound for detecting prenatal facial clefts in low-risk and high-risk populations. METHODS This study prospectively followed up a non-selected population, namely all pregnant women who underwent routine second-trimester prenatal ultrasound screening in the Utrecht region during the 2-year period from January 2007 to December 2008. ...

BACKGROUND The purpose of this study was to describe the association of MTHFR gene single nucleotide polymorphisms (C677T and A1298C) and maternal supplementary folate intake with orofacial clefts in the Iranian population. METHODS In this case-control study, peripheral venous blood was taken from 65 patients with orofacial clefts and 215 unaffected controls for DNA extraction and kept in EDT...

Background. The opportunity to provide free surgical care for orofacial clefts has opened a new vista and is enhanced by well-informed communities who are aware of the free surgical services available to them. It is the responsibility of cleft care providers to adequately inform these communities via a combination of community mobilization and awareness creation. Methods. This was a nationwide,...

1: The evidence base for intervention with respect to smoking and consanguinity. Meta-analyses reveal that passive smoking and consanguinity ARE both risk factors in OFC. Mossey, P.A. “Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis”. Sabbagh HJ, Hassan MH, Innes NP, Elkodary HM, Little J, Mossey PA Data extraction from studies reporting ...

BACKGROUND Surgical correction of orofacial clefts greatly mitigates negative outcomes. However, access to reconstructive surgery is limited in developing countries. The present study reviews epidemiological data from a single charitable organization, Smile Train, with a database of surgical cases from 33 African countries from 2001-2011. METHODS Demographic and clinical patient data were col...

Background: One of the most common congenital malformations, with widespread racial and regional variation is an orofacial cleft. The occurrence attributed to array environmental genetic factors. Blood grouping Rh factor are genetically determined. Any possible association clefts them helps in planning interventional services. Methods: A case control observational study was conducted on 111 sam...