نتایج جستجو برای: orphan male adolescent
تعداد نتایج: 384794 فیلتر نتایج به سال:
A 15-year-old boy was referred to our emergency department for evaluation of subcutaneous emphysema. The patient had presented with gradual onset of dull resting chest pain lasting for almost an hour. The nature of the pain subsequently changed to sharp and radiated to his throat. He had undergone a chest X-ray at the outside emergency department which was remarkable for subcutaneous emphysema....
BACKGROUND Health Canada has defined rare diseases as life-threatening, seriously debilitating, or serious chronic conditions affecting a very small number of patients (~1 in 2,000 persons). An estimated 9 % of Canadians suffer from a rare disease. Drugs treating rare diseases (DRDs) are also known as orphan drugs. While Canada is currently developing an orphan drug framework, in the United Sta...
BACKGROUND The pricing mechanism of orphan drugs appears arbitrary and has been referred to as a "black box". Therefore, the aim of this study is to investigate how drug- and disease-specific variables relate to orphan drug prices. Additionally, we aim to explore if certain country-specific pricing and reimbursement policies affect the price level of orphan drugs. METHODS Annual treatment cos...
Dominance relationships are common among primates, and are usually the result of resource competition. Adult male chimpanzees have pronounced dominance relationships, and can be ranked relative to one another in dominance hierarchies. Adult male chimpanzees achieve, and maintain, high rank through a combination of physical size, strength and political ability. Dominance in male chimpanzees has ...
Acute chest pain with very elevated troponin level and abnormal EKG in adult population is considered sine qua non to acute coronary syndrome (ACS) unless proved otherwise. Similar presentation in adolescent population is seen less often but raises suspicion for ACS. Most common etiology for chest pain with cardiac enzyme elevation in adolescent population is usually viral myopericarditis. The ...
Background & Aims: The purpose of this study was investigating the relationship of sensation seeking and self-regulation in delinquent and normal adolescent boys. Methods: In this descriptive-correlation study, 80 delinquent adolescent boys who were habitant in Mashhad Training and Improvement Association, Mashhad, Iran, were selected via random simple sampling method; and 80 normal male studen...
Extended sexual receptivity in primates is thought to facilitate paternity confusion, thus decreasing the risk of infanticide. However, females might also provide some indication of ovulation to attract preferred males during fertile periods. We examined female mate preferences across defined receptive periods (N = 59) in a group of wild Phayre's leaf monkeys (Trachypithecus phayrei crepusculus...
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4-95.2% across orphan categories. Clinic transfers were high...
BACKGROUND Orphan designated medicinal products benefit from regulatory and economic incentives for orphan drug development. Approximately 40% of orphan designations target rare neoplastic disorders, referring to rare cancers. In order to provide more insights in drugs for rare neoplastic disorders that are under development and to better understand the role of orphan designation in the develop...
1. Introduction 2. Economics of the pharmaceutical R&D process 2a. Costs and risks 2b. R&D returns 2c. The critical significance of patents in pharmaceuticals 3. The Orphan Drug Act of 1983 3a. Push and pull incentive programs 3b. Characteristics of the Orphan Drug Act 3c. Orphan drug designation and approvals 3d. Costs of orphan drugs 3e. Revenues from marketed orphan drugs 3f. Health benefits...
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