BACKGROUND Osteopontin is a secreted phosphoprotein that has a number of diverse biological functions, including cell signaling, mediation of cell adhesion, migration, and chemoattraction of monocytes/macrophages. Up-regulation of osteopontin expression by proximal tubular epithelium has been demonstrated in both human and rodent models of renal injury in association with macrophage influx. M...

A key event in bone resorption is the binding of osteoclasts to the mineral matrix of bone surfaces. A candidate for mediating this binding is osteopontin, a major cell- and hydroxyapatite-binding protein synthesized by osteoblasts. In support of this hypothesis is the fact that the synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin(D3), a substance that induces bone r...

OBJECTIVE Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to the pathogenesis of pulmonary hypertension by producing secreted factors. The aim of this study was to explore the role in pulmonary hypertension of extracellular matrix proteins released by senescent PA-SMCs. APPROACH AND RESULTS Polymerase chain reaction array analysis of human PA-SMCs undergoing replicativ...

The use of cancer biomarkers to anticipate the outlines of disease has been an emerging issue, especially as cancer treatment has made such positive steps in the last few years. Progress in the development of consistent malignancy markers is imminent because advances in genomics and bioinformatics have allowed the examination of immense amounts of data. Osteopontin is a phosphorylated glycoprot...

BACKGROUND We aimed to investigate the role of osteopontin in regulating mesenchymal stem cells transplanted to promote wound healing in diabetic mice. METHODS The mesenchymal stem cells of osteopontin knock-out (KO) and wild-type (WT) mice were isolated separately for in vitro culture and characterization. A skin wound on the back of mice was established by skin punching. In 27 osteopontin K...

OBJECTIVE This study aims to explore the effect of osteopontin on the inflammatory reaction of cartilage cells stimulated by LPS and its possible signal pathway. METHODS The inflammatory reaction of cartilage cells was induced by LPS, and then the cells were treated with OPN and PD98059 respectively. The expression of TNF-α, IL-1β and ERK1/2 were detected by ELISA or Western-blotting methods....

background: the conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (aml) mostly target tumor bulk but not leukemic stem cells (lscs). aberrant expression or activation of mediators such as osteopontin (opn) or pi3k/pten/akt/mtor pathway plays a key role in making prone to develop leukemia. preventing or treating cancer by curcumin (cur) has been suggest...

objective: osteopontin (opn) has been proposed to play a role in bone resorption. with regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement. materials and methods: fixed nickel-titanium closed coil springs (dentaurum ® ) capa-ble of delivering appr...

According to WHO, breast cancer is one of the most common forms in women. In 2020, 2.3 million women were diagnosed with and 685,000 deaths from disease reported worldwide. This research aims study dynamics concentration MMP8, osteopontin, Ca2+ ions, as well pH level patients during chemotherapy specific dental treatment. Materials methods. The involved 60 patients, both men All respondents div...

Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby producing fragments with novel chemotactic activity. Furthermore, osteopon...