As more and more substances have been shown in preclinical studies to be capable of preventing damage to the inner ear from exposure to noise, ototoxic drugs, ischemia, infection, inflammation, mechanical trauma and other insults, it is becoming very important to develop feasible and safe methods for the targeted delivery of drugs to specific regions in the inner ear. Recently developed methods...

Background: Hearing impairment, as one of the most common birth defects, is a hidden disability with negative impacts on speech and cognitive development. Objectives: The aim of this study was to assess the prevalence of sensorineural hearing loss (SNHL) and determine the associated risk factors among infants admitted to neonatal intensive care units (NICUs) and neonatal wards of teaching hospi...

Subjects receiving treatment with ototoxic agents were evaluated concurrently with conventional and high-frequency (> or = 8 kHz) behavioral threshold measures and with ABR to click and to 8, 10, 12, and 14 kHz tone-burst stimuli. Behavioral threshold data revealed ototoxic change in 51 percent of ears evaluated. Of these ears demonstrating behavioral change, 90 percent revealed concurrent ABR ...

Magnetic micelles with surface decorated by S-rich chelates sequester ototoxic cisplatin in aqueous solutions, and the isolation of cisplatin-saturated is steered external magnets.

Abstract Objectives Since its first appearance in Wuhan December 2019, SARS-CoV2 virus received great attention due to severe symptoms and high spread causing COVID-19 disease which all over the world like a pandemic. The causative is capable of human-to-human transmission via droplet direct contact suggesting that upper respiratory tract main site manifestations. There diversity clinical pictu...

Objective: socializing hearing loss examination and early detection to patients their families in deaftype B schools. Methods: A community service program the form of socialization was performed thefamily with deaf school type B, Surabaya, Indonesia. Pretest posttest wereconducted determine initial understanding post knowledge these people. We alsoasked participants fill on a questionnaire rega...

Objectives: CSOM is significantly associated with SNHL but mixed demographical associations being reported in literature.To determine the variations (age and gender) of among patients Study design setting: Cross-sectional observational study at Jinnah Postgraduate Medical Center, Karachi, Pakistan. Methodology: Using non-probability convenient sampling, diagnosed within six months between 10-50...

Background: Pseudoexfoliation syndrome (PEX) is a complex systemic disorder of the extracellular matrix primarily affecting eye and visceral organs. In this age-related disease fibrillar material produced accumulates in many ocular extraocular tissues. Objective: To study prevalence pseudoexfoliation among patients with sensorineural hearing loss. Patients Methods: A cross-sectional study, cond...

Several studies have reported an increased incidence of auditory dysfunction among HIV/AIDS patients. We used auditory HEI-OC1 cells in cell viability, flow cytometry and caspases 3/7-activation studies to investigate the potential ototoxicity of fourteen HIV antiretroviral agents: Abacavir, AZT, Delavirdine, Didenosine, Efavirenz, Emtricitabine, Indinavir, Lamivudine, Nefinavir, Nevirapine, Te...

Ouabain is a common tool to explore the pathophysiological changes in adult mammalian cochlea in vivo. In prior studies, locally administering ouabain via round window membrane demonstrated that the ototoxic effects of ouabain in vivo varied among mammalian species. Little is known about the ototoxic effects in vitro. Thus, we prepared cochlear organotypic cultures from postnatal day-3 rats and...