malignant mixed germ cell tumors,though rare overall, are the most common type of malignant ovarian neoplasms in young and adolescent girls. these tumors are rapidly growing and can metastasize. we report a case of 13-yr-old girl who presented at shkm gmc, nalhar, mewat, haryana, india in december 2013 with huge abdominal lump of a malignant mixed germ cell tumor comprising both immature terato...

Ovarian fibromas are the most common benign solid ovarian tumors, which preoperative diagnosis often is difficult. Ovarian fibromas, especially in bilateral cases, may be representative of Gorlin syndrome.Gorlin syndrome (GS) is a rare autosomal dominant disorder with predisposition to basal cell carcinomas (BCCs) and other various benign and malignant tumors. To report a case of a young patien...

Malignant mixed germ cell tumors,though rare overall, are the most common type of malignant ovarian neoplasms in young and adolescent girls. These tumors are rapidly growing and can metastasize. We report a case of 13-yr-old girl who presented at SHKM GMC, Nalhar, Mewat, Haryana, India in December 2013 with huge abdominal lump of a malignant mixed germ cell tumor comprising both immature terato...

background: ovarian cancer is the most common cause of cancer death worldwide. incidence of ovarian cancer is more common in postmenopausal women. premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. case presentation: the patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was mad...

the cytotoxicity activity of the essential oils from the leaves of achillea wilhelmsii c. koch were studied on six tumor cell lines and a normal cell line w

  This study was performed to determine the incidence and anatomo-pathological aspects of the reproductive system tumors in commercial laying hens. Post mortem examination of 1041 laying hens revealed neoplasms of the ovaries and the oviduct in 52 (4.99%) cases. From these, ovarian adenocarcinoma was found in 14 cases, granulosa cell tumor in 7 cases, theca cell tumor in 1 case and Marek's dise...

Background and objectives: Black cumin is a herbaceous plant with scientific name Nigella sativa, that contains compounds such as fixed oils, proteins, alkaloids, saponins and essential oils. It has numerous health benefits including antioxidant and anti-inflammatory properties. In the current study, we have evaluated the cytotoxic effects of compounds isolated from th...

Follistatin (FST), a folliculogenesis regulating protein, is found in relatively high concentrations in female ovarian tissues. FST acts as an antagonist to Activin, which is often elevated in human ovarian carcinoma, and thus may serve as a potential target for therapeutic intervention against ovarian cancer. The breast cancer susceptibility gene 1 (BRCA1) is a known tumor suppressor gene in h...

Chemotherapy resistance is a major obstacle for the treatment of ovarian cancer patients. Combination of drugs which can exert synergistic effect can be a promising strategy to overcome this resistance. In this study, we report significantly enhanced activation of Janus kinase 2 (JAK2) and its downstream target signal transducer and activation of transcription 3 (STAT3) in tumor cells isolated ...

The aim of the present study was to evaluate the efficacy of paclitaxel combined with curcumin (CUR) against drug resistance in ovarian cancer cells. PLGA-phospholipid-PEG nanoparticles were prepared using the nano precipitation method. The size and morphology of the nanoparticles were determined using a transmission electron microscope and particle size analyzer. The encapsulation efficiency o...