PAGE INTRODUCTION .................................................................. I35 Coincidence of widely separated regions. , 138 Coincidence in the second chromosome. 146 Coincidence in the third chromosome. 148 Coincidence in other forms 148 The mechanism of crossing over 148 Triple crossing over .: .. I49 Maximum and minimum coincidence. I53 The distance between the breaking points in ...

The achievements of a group frequently depend on the efforts of just a few members but represent a public good benefit to all members. This paper investigates such a situation: the private provision of a public good whose level is determined as the maximum effort made by a group member. Members’ costs of effort are envisioned as either commonly known or privately known. With perfect information...

The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among ...

spo16 mutants in yeast were reported to have reduced map lengths, a high frequency of nondisjunction in the first meiotic division, and essentially unchanged coefficients of coincidence. Were all crossing over in yeast subject to interference, such data would suggest that the "designation" of recombination events to become crossovers is separable from the "implementation" of that crossing over....

Electronic order book trading has evolved in being recognized as the best-practice for trading small and mid-sized orders. Yet, this mechanism does not properly address the needs of large-sized orders which tend to execute off order book in over-the-counter markets. Order book trading provides for public price discovery but not for quantity discovery. Off book executions generally fragment the ...

BACKGROUND A Polypill is proposed for the primary prevention of cardiovascular disease in people judged to be at risk on account of their age alone. Its efficacy in reducing cholesterol and blood pressure is uncertain. METHODS We conducted a randomized double-blind placebo-controlled crossover trial of a Polypill among individuals aged 50+ without a history of cardiovascular disease and compa...

Preference formation is a complex problem as it is subjective, involves emotion, is led by implicit processes, and changes depending on the context even within the same individual. Thus, scientific attempts to predict preference are challenging, yet quite important for basic understanding of human decision making mechanisms, but prediction in a group-average sense has only a limited significanc...

Knowledge reuse of cancer trial designs may benefit from a temporal understanding of the evolution of the target populations of cancer studies over time. Therefore, we conducted a retrospective analysis of the trends of cancer trial eligibility criteria between 1999 and 2014. The yearly distributions of eligibility concepts for chemicals and drugs, procedures, observations, and medical conditio...