murraya koenigii l. (rutaceae), commonly known as curry leaf tree, closely associated with south india where the word “curry” originates from the tamil “kari” for spiced sauces. curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. curry leaf has a potential role in the treatment of diabetes. reser...

objective(s) the aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (stz)-induced diabetic rat. materials and methods a total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). diabetes was induced by injection of single dose of stz. exercise was...

In the second experiment as reported in the previous chapter, an anti cataract activity of Captopril against oxidant stress induced cataract was investigated attributed to its antioxidant properties. The antioxidant property of Captopril is greatly influenced by the presence of thiol group in its structure which helps to interact with lens specific enzymes and proteins as well. After absorption...

An efficient protocol to synthesize iodohydrins from alkenes is presented. Reactions were conducted in aqueous media using safe and readily available sodium iodide (the most abundant form of the element), and a highly convenient oxidant such as hydrogen peroxide. Addition of a protic acid triggers a faster and efficient process, a role formally related to that played by haloperoxidase enzymes i...

The molecular mechanisms by which a variety of naturally-occurring dietary compounds exert chemopreventive effects have been a subject of intense scientific investigations. Induction of phase II detoxification and anti-oxidant enzymes through activation of Nrf2/ARE-dependent gene is recognized as one of the major cellular defense mechanisms against oxidative or xenobiotic stresses and currently...

Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demonstrate the effect of TBWE on anti-adipogenesis and pro-oxidant enzyme in 3T3-...

Albendazole (ABZ) is a therapeutic benzimidazole used to treat giardiasis that targets β-tubulin. However, the molecular bases of ABZ resistance in Giardia duodenalis are not understood because β-tubulin in ABZ-resistant clones lacks mutations explaining drug resistance. In previous work we compared ABZ-resistant (1.35, 8, and 250 μM) and ABZ-susceptible clones by proteomic analysis and eight p...

Antioxidants function as blockers of radical processes and eliminate harmful reactive oxygen species (ROS) produced during normal cellular metabolism. A complex antioxidant defence system has evolved to protect the cellular homeostasis. This system includes antioxidant enzymes (AOEs), such as superoxide dismutases (SODs), which are intracellular MnSOD and CuZnSOD and extracellular ECSOD, H2O2 s...

SUMMARY Oxidative stress has been increasingly implicated in the pathogenesis of lung diseases. Antioxidant mechanisms and their regulation are poorly characterized in the human lung, but they may be important in the development and progression of pulmonary diseases. The present study was designed to investigate the regulation of the most important antioxidant enzymes (AOEs), superoxide dismuta...

The brain's anti-oxidant response to highly elevated oxygen (O2) partial pressures is poorly understood. In this study we hypothesized that hyperbaric O2 (HBO2) would stimulate superoxide dismutase (SOD) transcription in the oxidative stress-sensitive rat hippocampus and measured the time course and extent of the changes in hippocampal mRNA for all three SOD isoforms and total SOD enzyme activi...