background: superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (sod) enzymes. controversial results have been reported regarding the tissue and plasma concentration of sod in patients with breast cancer. methods: venous blood was obtained from study participants and activity of sod enzyme was determined in 100 women. comparison was made be...

background: the contribution of neuroinflammation in alzheimer’s disease (ad) has been widely reported. the effects of female gonadal hormones in both neuroinflammation and brain cognitive functions have also been well considered. objectives: in the present study, the possible protective role for endogenous ovarian hormones against learning and memory impairment as well as brain tissues oxidati...

background smoking is an established risk factor for cardiovascular diseases and metabolic syndrome. objectives here we aimed to assess the effect of 3-month aerobic training on c-reactive protein (crp) level and total antioxidant capacity (tac) in male smokers. results aerobic training resulted in a significantly increased tac (p < 0.001), but crp remained unchanged (p = 0.96). conclusions des...

chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. in this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (aml). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. all patients received cytarabine and...

abstract        background and objective: doxorubicin (dox) is an effective anticancer drug. it has been shown that  a short-term exercise performed prior to dox-treatment has no effect on cardiotoxicity in young rats. in the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on dox-induced oxidative damage in cardiac t...

breast cancer is the most common cancer in women. several risk factors such as age, family history of breast cancer, marital status, early menarche and late menopause are related to breast cancer. obesity is also a main health problem associated with breast cancer incidence and subsequent mortality. association between obesity and expansion of breast cancer may be due to excessive sex steroid h...

the number of patients with end-stage renal disease is growing rapidly in asia. patients with end stage renal disease failure (esrd) undergoing long term hemodialysis (hd) are at risk for high oxidative stress. there is paucity of information with regard to oxidative stress during hd. therefore, the aim of the present study was to evaluate catalase enzyme activity in erythrocytes and the total ...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. du is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. recent studies showed that uranium induces biological changes in many different target tissues, such as the kidney...

objective(s):therapies with high levels of oxygen are commonly used in the management of critical care. however, prolonged exposure to hyperoxia can cause acute lung injury. although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (hali).   materials a...