UNLABELLED Supplemental oxygen maintained during and for 2 h after colon resection halves the incidence of nausea and vomiting. Whether supplemental oxygen restricted to the intraoperative period is sufficient remains unknown. Similarly, the relative efficacy of supplemental oxygen and ondansetron is unknown. We tested the hypothesis that intraoperative supplemental oxygen reduces the incidence...

The effects of the administration of 0.5 or 1 mg/kg of 1-thyroxine for 3 or 16 days were studied in 55 New Zealand white rabbits. Heart size was 29% above control after 16 days of 1-thyroxine, despite lower body weights. In an anesthetized open-chest animal, regional microspectro-photometric observations of small arteries and veins to determine oxygen extraction were combined with regional bloo...

Transtracheal administration of oxygen is a new technique for long term treatment. Twenty patients with hypoxaemia due to chronic obstructive airways disease were studied while receiving oxygen through a microcatheter inserted percutaneously into the trachea. By bypassing most of the dead space and avoiding oxygen wastage at the face this method of delivery reduced oxygen requirements by roughl...

Excessive oxygen administration in hypercapnic chronic obstructive pulmonary disease predisposes to worsening respiratory failure during intercurrent respiratory illness. Chronic hypercapnia is thought to downregulate carbon dioxide chemoreceptor sensitivity, adversely affecting respiratory function/mechanics and worsening ventilation-perfusion inequality. These patients are dependent on hypoxi...

The routine administration of oxygen to patients presenting with features of acute coronary syndrome (ACS) is a practice that is deeply embedded in the routine of frontline health care professionals, and it has been a primary intervention for persons with ACS for more than 100 years. It is noteworthy that this tradition was supported by the American Heart Association (AHA) from 1975 through 200...

We asked whether crystalloid administration improves tissue oxygen extraction in endotoxicosis. Four groups of anesthetized pigs (n = 8/group) received either normal saline infusion or no saline and either endotoxin or no endotoxin. We measured whole body (WB) and gut oxygen delivery and consumption during hemorrhage to determine the critical oxygen extraction ratio (ERO2 crit). Just after onse...

BACKGROUND Routine administration of supplemental oxygen to parturients undergoing Caesarean section under spinal anaesthesia has been criticised in recent times. OBJECTIVES To assess the need for routine supplementary oxygen in healthy women undergoing Caesarean section under spinal anaesthesia in resource challenged setting and establish the efficacy of administration of oxygen at 4L/min. ...