UNLABELLED The P300 results from focusing attention on rare stimuli in the midst of other frequent stimuli; it tests recent attention and memory, both of which depend on discriminating among verbal or nonverbal stimuli. AIM To compare the P300 with verbal and nonverbal stimuli in normal-hearing adults. MATERIAL AND METHOD A prospective study was made of 15 male subjects aged from 22 to 55, ...

The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene. Animals nullizygous for p300 died between days 9 and 11.5 of gestation, exhibiting defects in neurulation, cell proliferation, and heart development. Cells derived from p300-deficient embry...

AIMS/INTRODUCTION Given the high prevalence of diabetes and burn injuries worldwide, it is essential to dissect the underlying mechanism of delayed burn wound healing in diabetes patients, especially the high glucose-induced hypoxia-inducible factor 1 (HIF-1)-mediated transcription defects. MATERIALS AND METHODS Human umbilical vein endothelial cells were cultured with low or high concentrati...

The discrepancy in the literature concerning the sensitivity of delayed P300 latency in dementia revolves around the variability of P300 latency in normal elderly. Previous studies, which have produced conflicting results, have utilized different P300 paradigms and different methods for measuring P300 latency. We demonstrate that the reported differences in the variability of P300 latency in no...

BACKGROUND The P300 component of the auditory evoked potential is an indicator of attention dependent target processing. Only a few studies have assessed cognitive function in substituted opiate addicts by means of evoked potential recordings. In addition, P300 data suggest that chronic nicotine use reduces P300 amplitudes. While nicotine and opiate effects combine in addicted subjects, here we...

OBJECTIVE Transcriptional coactivator p300 has been shown to play a variety of roles in the transcription process and mutation of p300 has been found in certain types of human cancers. However, the expression dynamics of p300 in breast cancer (BC) and its effect on BC patients' prognosis are poorly understood. METHODS In the present study, the methods of tissue microarray and immunohistochemi...

Summary The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A KAT3B) maintain gene expression programs through lysine acetylation of chromatin transcriptional regulators by scaffolding functions mediated several protein-protein interaction domains. Small molecule inhibitors that target some these domains have been developed; however, they cannot completely ablat...

Diabetic cardiomyopathy, structurally characterized by cardiomyocyte hypertrophy and increased extracellular matrix (ECM) protein deposition, eventually leads to heart failure. We investigated the role of transcriptional coactivator p300 and its interaction with myocyte enhancer factor 2 (MEF2) in diabetes-induced cardiomyocyte hypertrophy. Neonatal rat cardiomyocytes were exposed to variable l...

BACKGROUND Overall and left temporal scalp area reductions of P300 have been demonstrated in schizophrenia. P300 amplitude and topography in psychotic affective disorder, a crucial comparison in assessing the specificity of P300 abnormalities to schizophrenia, are not well studied. METHODS P300 was recorded from 35 schizophrenic, 20 psychotic manic, and 30 control subjects. All were right-han...

Skeletal myogenesis is a highly ordered process which specifically depends on the function of transcriptional coactivator p300. Previous studies have established that Akt/protein kinase B (PKB), a positive regulator of p300 in proliferating cells, is also important for proper skeletal muscle development. Nevertheless, it is not clear as to how the p300 is regulated by myogenic signaling events ...