We assessed synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) properties during synaptogenesis to describe the development of individual glutamatergic synapses on rat hippocampal CA1 principal neurons. Pharmacologically isolated AMPAR-mediated glutamatergic synaptic currents [evoked by stimulation of the Schaffer Collateral pathway, excitatory postsynaptic currents (EP...

P pili are hair-like adhesive structures that are assembled on the outer membrane (OM) of uropathogenic Escherichia coli by the chaperone-usher pathway. In this pathway, chaperone-subunit complexes are formed in the periplasm and targeted to an OM assembly platform, the usher. Pilus subunits display a large groove caused by a missing β-strand which, in the chaperone-subunit complex, is provided...

Hereditary pyrimidine 5'-nucleotidase (P5'N) deficiency is the most frequent abnormality of the red cell nucleotide metabolism causing hereditary non-spherocytic haemolytic anaemia. The disorder is usually characterised by mild-to-moderate haemolytic anaemia associated with the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. The precise mechanisms leading t...

Microwave irradiation was used to synthesize PEG-PCL and PEG-PLA copolymers that are composed of biodegradable polymers including PEG, PLA, and PCL. These copolymers were used for loading docetaxel in nanoparticles. Single emulsion-solvent evaporation technique was applied for preparing the PEG-PLA and PEG-PCL mixed nanoparticles (micelles and polymersomes) with different proportions, including...

a person, who is talented, performs in a certain capacity above the norm. talent is different from intelligence which is a response to a circumstance using knowledge and skill. the attributes of talent are exceptional memory, rapid processing speed, and high motivation, an affinity for learning, creativity and optimal cognition. there is some proof suggests that certain aspects of talent are re...

We study the stability number, chromatic number and clique cover of graphs with no induced P5 and diamonds. In particular, we provide a way to obtain all imperfect (P5, diamond)-free graphs by iterated point multiplication or substitution from a /nite collection of small basic graphs. Corollaries of this and other structural properties, among which a result of Bacs1 o and Tuza, are (i) combinat...

Structural comparisons between bacteriophage PRD1 and adenovirus have revealed an evolutionary relationship that has contributed significantly to current ideas on virus phylogeny. However, the structural organization of the receptor-binding spike complex and how the different symmetry mismatches are mediated between the spike-complex proteins are not clear. We determined the architecture of the...

Recombinant staphylokinase (SakSTAR) variants obtained by site-directed substitution with cysteine, in the core (lysine 96 [Lys96], Lys102, Lys109, and/or Lys135) or the NH(2)-terminal region that is released during activation of SakSTAR (serine 2 [Ser2] and/or Ser3), were derivatized with thiol-specific (ortho-pyridyl-disulfide or maleimide) polyethylene glycol (PEG) molecules with molecular w...

(246/250 words) 16 We assessed synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionate 17 receptor (AMPAR) properties during synaptogenesis in order to describe the 18 development of individual glutamatergic synapses on rat hippocampal CA1 principal 19 neurons. Pharmacologically isolated AMPAR-mediated glutamatergic synaptic currents 20 (evoked by stimulation of the Schaffer Collateral pathw...

The Independent Set problem is NP-hard in general, however polynomial time algorithms exist for the problem on various specific graph classes. Over the last couple of decades there has been a long sequence of papers exploring the boundary between the NPhard and polynomial time solvable cases. In particular the complexity of Independent Set on P5-free graphs has received significant attention, a...