Background: P53, p63, and p73 transcription factors which are belong to The p53 family, are conserved during evolution. They have important roles in many molecular and cellular functions, including tumor suppression, the development of epithelial cell layers, and the development of central nervous system and immune system. Studies show these molecules also have role in maintaining the genomic i...

Background: Nano-particle Titanium Dioxide (TiO2) is a noncombustible, odorless powder that is widely used in different fields of industries. Previous reports showed that chronic exposure to TiO2 adversely impacts the testicular tissue and down-regulates the antioxidant capacity and down-regulates the endocrine status of the testicles. Present study was designed in order to identify the role of...

To investigate the effect of shikonin on oxidative damage lung cancer cells and promotes cell senescence through p53/p21Waf signaling pathway. The adenocarcinoma A549 were cultured made into suspension. for 12 h, 24 h 48 respectively with different concentrations (0 μm, 2 μm 4 μm) activity was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide method. cycle each group mea...

Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

Cyclooxygenase-2 (COX-2) has a pivotal role in the pathogenesis of the lung cancer. It is known that COX-2 negatively regulates the activity of a number of tumor suppressors, including p53. Consequently, inhibition of COX-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. In this regard, we investigated the effect of COX-2 signaling blockade on p53 and COX-2 e...

introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/...

Selectively targeting the cancer cells by reactivating cell killing function of p53 protein - IJPCA- Print ISSN No: 2394-2789 Online No:- 2394-2797 Article DOI 10.18231/j.ijpca.2022.010, International Journal Pharmaceutical Chemistry and Analysis-Int J Pharm Chem Anal

Background:Non-Melanoma Skin Cancer (NMSC), the most prevalent types being Squamous Cell Carcinoma (SCC) and Basal Cell Carcinoma (BCC), is the most common type of malignancy in human beings. These neoplasms are more frequent in the elderly and fair skinned people and mainly occur on sun-exposed sites of the body. Ultraviolet B (UVB) has a wel...

abstract introduction. p53 has been known as a tumor suppressor gene and also ki-67 is a cell cycle regulator. the aim of present study was to investigate p53 and ki-67 protein expression in the epithelial lining of odontogenic cysts and its correlation with their biologic behavior and the degree of inflammation within the cyst wall. methods. p53 and ki-67 immunoreactivity in 58 odontogenic cys...