AMERICAN JOURNAL OF CRITICAL CARE, January 2007, Volume 16, No. 1 39 • OBJECTIVE To review the literature on the limitations and consequences of packed red blood cell transfusions, with particular attention to critically ill patients. • METHODS The PubMed database of the National Library of Medicine was searched to find published articles on the indications, clinical utility, limitations, and c...

Anaemia may increase the risk of tissue hypoxia in preterm infants. The effect of transfusion on circulation was studied in 33 preterm infants with a mean (SD) gestational age of 29 (5) weeks (range 26-34), birth weight 1153 (390) g (range 520-1840), and postnatal age of 48 (21) days (range 19-100). Packed cell volume, blood viscosity (capillary viscometer), cardiac output, and cerebral blood f...

introduction: significant perineal injuries and major pelvic fractures resulting from blunt trauma manifest a high-energy injury. open pelvic fractures (with perineal injury) are associated with higher mortality rates of 40 to 60 %. methods: this study was a review of patients with multiple traumas comprising of major pelvic fracture and severe perineal injuries (shahid kamyab hospital in mashh...

AMERICAN JOURNAL OF CRITICAL CARE, January 2007, Volume 16, No. 1 39 • OBJECTIVE To review the literature on the limitations and consequences of packed red blood cell transfusions, with particular attention to critically ill patients. • METHODS The PubMed database of the National Library of Medicine was searched to find published articles on the indications, clinical utility, limitations, and c...

Because raised plasma concentrations of atrial natriuretic peptide indicate volume expansion, we studied the effect of red cell transfusion on plasma atrial natriuretic peptide concentration, packed cell volume, and intravascular volume in eight preterm infants. Red cell transfusion increased red cell mass, packed cell volume and erythrocyte count, but decreased plasma volume. Total blood volum...

We have investigated the effect of treatment with tranexamic acid, an inhibitor of fibrinolysis, on blood loss, blood transfusion requirements and blood coagulation in a randomized, double-blind, placebo-controlled study of 42 patients after total knee arthroplasty. Tranexamic acid 15 mg kg-1 (n = 21) or an equivalent volume of normal saline (n = 21) was given 30 min before surgery and subseque...

An 82-year-old man with a low-grade malignant non-Hodgkin lymphoma and an IgG3 lambda monoclonal gammopathy presented a recently acquired bleeding tendency, characterized by recurrent epistaxis, easy bruising, and episodes of melena, requiring packed red blood cell transfusions. Coagulation studies showed a von Willebrand factor (vWF) defect (Ivy bleeding time, > 15 minutes; vWF antigen [vWF:Ag...