Paliperidone which is the active metabolite of risperidon is one of the novel antipsychotics. Controlled clinical studies proved its effectiveness on decreasing the positive and negative symptoms of schizophrenia. Some studies and case reports, reported its cardiovascular and cardiometabolic side effects. Cardiac tamponade, that may be mortal, wasn't reported as a side effect with paliperidone ...

Paliperidone palmitate, the long-acting injectable form of paliperidone (PLAI), is approved for once-monthly intramuscular injection [1]. Several studies suggest that the loading dose regimen for PLAI does not lead to higher rates of extrapyramidal symptoms (EPS)related treatment-emergent adverse events (TEAEs) than the oral formulation [2]. However, reports of post-injection delirium/sedation ...

Paliperidone is a BCS-II drug. It means paliperidone poorly water soluble and hence shows problem in absorption as well permeation through GIT which together contributes for its lower oral bioavailability. drug, oil oleic acid, surfactant labrasol co labrafil m 1944 were taken formulation done. From the emulsification time study concentration of Smix increases decreases. Further I found that F3...

OBJECTIVES The long-term safety, tolerability, and efficacy of paliperidone extended-release (ER) were evaluated in Chinese patients with schizophrenia. METHODS Patients (aged ≥18 years) with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria) who had completed run-in (8-week), stabilization (6-week), and double-blind (DB) phases (variable) of a phase-3...

I n the report by Yin et al, 1 the statement that “many clinicians may misinterpret these directions (in paliperidone palmitate product monograph) to mean that these intramuscular sites (deltoid or gluteal) are interchangeable, and thus therapeutically equivalent” is, in our opinion, not correct. We are writing to clarify some statements from the Yin et al article concerning the deltoid versus ...

BACKGROUND The analysis of prescribing patterns in entire catchment areas contributes to global mapping of the use of antipsychotics and may improve treatment outcomes. OBJECTIVE To determine the pattern of long-term antipsychotic prescription in outpatients with schizophrenia in the province of Tarragona (Catalonia-Spain). METHODS A naturalistic, observational, retrospective, non-intervent...

Title: Long-term safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate: a one-year open-label study in patients with schizophrenia Authors:

Objective: Erectile dysfunction is a usual side effect of antipsychotic medications; this causes patients to avoid using drugs. The aim study investigate the effects iloperidone, paliperidone and loxapine on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions vas deferens in mice.Materials Methods: mice were randomly divided into expe...

Aims Antipsychotic treatment is associated with metabolic disturbance, clear differences observed between drugs in the adult population. However, degree to which alterations occur different antipsychotics children and adolescents unclear. As such, we aimed compare rank based on their endocrine side-effects when used of schizophrenia this age Methods We searched MEDLINE, EMBASE, PsycINFO from in...