Sir, Tegafur, a fluorinated pyrimidine analogue of 5Fluorouracil (5-FU), is metabolized in vivo with biotransformation to 5-FU (1). It is effective in the treatment of gastrointestinal carcinoma, with the advantages of low myelosuppression and lack of immunosuppression. The cutaneous adverse effects of Tegafur include stomatitis, dry skin, disseminated rash, alopecia, photosensitivity, palmopla...

BACKGROUND Hereditary palmoplantar keratodermas (HPPK) are relatively frequent in Slovenia; however, the papulosa type of HPPK is rare. Epidemiological data are scarce; a population study in Croatia revealed a prevalence of 1.17/100,000 inhabitants. According to the preliminary data, it seems that HPPK papulosa is more common in Slovenia than in other countries. Efforts were made to identify al...

Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disease that presents clinically with palmoplantar keratoderma and periodontitis results in early-onset dental loss. PLS management difficult. We report 30-year-old female who had unfavourable response to topical keratolytic creams, oral isotretinoin narrow-band ultraviolet-B (NB-UVB) phototherapy but showed significant clinical impr...

DESCRIPTION We report the case of a 28-year-old man presenting to our hospital with refractory diffuse hyperkeratosis of palms and soles. He reported first appearance in early childhood. His first-born daughter also developed hyperkeratosis on palms and soles directly after birth. No other family member seems to be affected by similar skin lesions. Clinically, our patient presented diffuse hype...

BACKGROUND Several genetic defects have been identified in the glycosylphosphatidylinositol (GPI) anchor synthesis, including mutations in PIGO encoding phosphatidylinositol glycan anchor biosynthesis class O protein. These defects constitute a subgroup of the congenital disorders of glycosylation (CDG). Seven patients from five families have been reported carrying variants in PIGO that cause a...

florid cutaneous papillomatosis (fcp), is a rare cutaneous marker of internal malignancy. the underlying cancer is usually intra-abdominal (most often gastric in origin), and evolves parallel to the fcp. there is a common association between fcp and the other two eruptive paraneoplastic syndromes, i.e.malignant acanthosis nigricans and the sign of leser-trelat. it seems possible that these synd...

Sir, Spiny keratoderma is a rare disease characterized by keratotic spicules resembling a “music box spine” located on the palms and soles (1). This entity has been reported under several different names, such as punctate keratoderma (2), punctate porokeratotic keratoderma (3), palmar filiform hyperkeratosis (4), and spiny keratoderma of the palms and soles (1). We present here a case of spiny ...