Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Herein, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. Hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic...

Pancreatic neuroendocrine neoplasms (PanNENs) are rare and heterogeneous diseases that account for less than 2% of all cases pancreatic cancer only 30% digestive neoplasia, even if their incidence prevalence continue to rise globally [...]

background: pancreatic anastomosis leakage and fistula formation following  pancreaticoduodenectomy (whipple’s procedure) is a common complication. delay in timely diagnosis and proper management is associated with high morbidity and mortality. to report our experience with management of pancreatic fistula following whipple’s procedure. materials and methods: in this retrospective study, medica...

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Background: Pancreatic carcinoma is the fourth-leading cause of cancer death in the United States and due to its late presentation, only few patients would be candidates for the curative treatment of pancreactomy. Monoclonal antibodies have brought hope to targeted therapy.Objectives: To identify new biomarkers, a panel of monoclonal antibodies was genera...

Pancreatic cancer is one of common malignant neoplasms. It characterized by poor prognosis and high mortality, which mainly due to detection in an advanced stage. This review presents epidemiological clinical characteristics pancreatic cancer, as well current strategies systemic treatment disease, including first- second-line chemotherapy, molecularly targeted therapies immunotherapy.

The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. Comparison of the chemosensitivity of PANC-1 cells to its wild type p53 transfectants showed that wt-p53 expressing transfectants are more sensitive to both Etoposide and Doxorub...

mucoepidermoid carcinoma of the pancreas is rare. here, a 63-year-old woman with left upper abdominal pain and abdominal distension is presented. her mucoepidermoid carcinoma was located at the left upper abdomen, arising from the pancreatic body and tail without invasion of pancreatic capsule. on pathologic examination, the tumor consisted of three types of cells, the majority being poorly dif...

malignant tumors of pancreas are usually primary neoplasms and pancreatic metastases are rare findings. we are reporting a case of squamous cell carcinoma (scc) of the esophagus with pancreatic metastasis. a 59-year old woman was admitted with chief complaint of abdominal pain and mass. she was a known case of esophageal scc since 4 years before when she had undergone transthoracic esophagectom...