Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States. Mutations in the K-ras oncogene occur in 85% of pancreatic adenocarcinomas and have also been identified in 75% of pancreatic ducts with mucinous cell hyperplasia seen in association with chronic pancreatitis. We identified K-ras mutations in 65% of duct lesions associated not only with chronic pancreatit...

Tumors arising from the pancreatic endocrine (islet) cells represent a heterogeneous group of lesions. Some tumors present with well characterized syndromes, while others appear to be nonfunctioning. Eighteen patients with pancreatic endocrine tumors who received surgical treatment at Kurume University Hospital during a 24-year period were reviewed. There were 10 patients with nonfunctioning tu...

Clinical and radiologic examinations cannot reliably distinguish benign or inflammatory pancreatic disease from carcinoma. The increased use of pancreatic fine needle aspiration (FNA) along with advances in imaging techniques and the introduction of endoscopic ultrasound guidance have led to significantly better detection and recognition of pancreatic masses. Consequently, pancreatic cytopathol...

Clinical and radiologic examinations cannot reliably distinguish benign or inflammatory pancreatic disease from carcinoma. The increased use of pancreatic fine needle aspiration (FNA) along with advances in imaging techniques and the introduction of endoscopic ultrasound guidance have led to significantly better detection and recognition of pancreatic masses. Consequently, pancreatic cytopathol...

Introduction. While the incidence of pancreatic cystic lesions has steadily increased, we sought to evaluate the changes in their surgical management. Methods. Patients with pancreatic cystic lesions who underwent surgical resection from 2003 to 2013 were identified. Clinicopathologic factors were analyzed and compared to a similar cohort from 1992 to 2002. Results. There were 134 patients with...

Clinical and radiologic examinations cannot reliably distinguish benign or inflammatory pancreatic disease from carcinoma. The increased use of pancreatic fine needle aspiration (FNA) along with advances in imaging techniques and the introduction of endoscopic ultrasound guidance have led to significantly better detection and recognition of pancreatic masses. Consequently, pancreatic cytopathol...