Mutations in the AT-rich interactive domain 1A gene, which encodes a subunit of the Switch/Sucrose nonfermentable chromatin remodeling complex, can result in loss of protein expression and are associated with different cancers. Here, we used immunohistochemistry to investigate the significance of AT-rich interactive domain 1A loss in 73 pancreatic ductal adenocarcinoma cases with paired paracan...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Nodal involvement of extranodal marginal zone lymphoma with extreme plasmacytic differentiation (Mott cell formation) simulating plasma cell neoplasm and lymphoplasmacytic lymphoma TO THE EDITOR: Plasmacytic differentiation is not a rare feature of extranoda...

The duodenum is infrequently affected by malignant lymphoma, and follicular lymphomas of the duodenum are rare histological subtypes. There are no reported cases of collision of follicular lymphoma and other tumors in the ampulla of Vater. A 57-year-old Japanese man presented with jaundice, and abdominal computed tomography revealed a tumor of the ampulla of Vater invading the pancreatic head w...

non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...

BACKGROUND Five percent of pancreatic neoplasms are non- adenocarcinoma tumors. Clinical presentation and imaging characteristics of these tumors are similar to adenocarcinoma. This study aims at evaluating the results and efficacy of Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) in diagnosing the pancreatic non-adenocarcinoma tumor in patients with solid pancreatic mass. METH...

In the presence of a pancreatic tumor, the main diagnostic problem is to determine the benign o malignant nature of the lesion, and then to evaluate its resectability. A preoperative biopsy was usually rejected based on the fact that negative results do not exclude malignancy, that such biopsy may hamper the possibility of curative surgery because of potential seeding along the biopsy s traject...

Background and Aim: Lymphoma is the third most common childhood malignancy with extranodal involvement in 50%. Nonetheless, pancreatic lymphoma either as primary disease or secondary highly unusual, its presentation acute pancreatitis exceedingly rare children (only 10 cases have been reported so far). We report an unusual case of Non-Hodgkin a 4-yr boy masquerading pancreatitis. Case report: H...

In the presence of a pancreatic tumor, the main diagnostic problem is to determine the benign o malignant nature of the lesion, and then to evaluate its resectability. A preoperative biopsy was usually rejected based on the fact that negative results do not exclude malignancy, that such biopsy may hamper the possibility of curative surgery because of potential seeding along the biopsy’s traject...

Long-term studies of the carcinogenicity of N-methyl-N-nitrosourea (MNU) in inbred guinea pigs were undertaken to develop an animal model of pancreatic adenocarcinoma. MNU, freshly, dissolved in 0.015 M sodium citrate buffer, pH 6.0, was administered by gavage once weekly at a dose of 10 mg/kg body weight to inbred strain 13 guinea pigs. By 27 weeks, 54% of guinea pigs given MNU weekly died, mo...