hallervorden-spatz syndrome is a disorder characterized by dystonia, parkinsonism, and iron accumulation in the brain. the disease is caused by mutations in gene encoding pantothenate kinase 2 (pank2) and patients have pantothenate kinase-associated neurodegeneration. we present an 8-year-old boy with progressive muscle dystonia, neuroregression, frequent fall and multiple injury marks of diffe...

Maspin is expressed aberrantly in pancreatic ductal adenocarcinoma (PDAC), and its function is still unknown. To explore the role of maspin in PDAC, we constructed wild-type maspin-expressing Panc-1 clones (Panc-1-maspin) by transfecting maspin cDNA into Panc-1, a PDAC-derived cell line that lacks maspin expression. As a control, mock-transfected clones (Panc-1-mock) were constructed using the ...

During the course of experimental work on acquired hypotrichosis and canities, it was noted that in discoid lupus erythematosus of the scalp there was improvement of the inflammatory phase of the disease associated with calcium pantothenate therapy. Following this, a series of patients with subacute and localized and disseminated discoid lupus crythematosus was studied with oral calcium pantoth...

The extracellular matrix protein thrombospondin (TSP) plays an important role in a variety of biological processes, including cell-cell and cell-matrix interactions. The biological role of TSP-2 in invasion and metastasis is poorly understood, while it is known that TSP-1 regulates a proteolytic cascade that allows tumor cells to invade and metastasize. In this study, we examined the role of TS...

As Plantas Alimentícias Não Convencionais (PANC) consistem em um conjunto de espécies grande valor nutricional, socioeconômico e cultural têm sido cada vez mais inseridas nos debates nacionais internacionais sobre alimentação adequada produção sustentável. Nesse artigo, as PANC são apresentadas como uma estratégia para diversificação dos sistemas produção, promoção autonomia no campo nas cidade...

Mutants lacking the first enzyme in de novo purine synthesis (PurF) can synthesize thiamine if increased levels of pantothenate are present in the culture medium (J. L. Enos-Berlage and D. M. Downs, J. Bacteriol. 178:1476-1479, 1996). Derivatives of purF mutants that no longer required pantothenate for thiamine-independent growth were isolated. Analysis of these mutants demonstrated that they w...

Neste trabalho, foi avaliado o potencial das plantas alimentícias não convencionais (PANC) no fornecimento de recursos para as abelhas e seu uso na intensificação ecológica. O Assentamento São José da Boa Morte (Cachoeiras Macacu, Estado do Rio Janeiro, Brasil) tomado como estudo caso, onde realizado os levantamentos PANC espontâneas calendário cultivo comunidade. Foram encontradas 28 espécies ...

Neuropeptides and their corresponding G protein-coupled receptors are increasingly implicated in the autocrine/paracrine stimulation of growth of human cancers. Using K-Ras mutated human pancreatic ductal adenocarcinoma cell line PANC-1 as a model system, we demonstrate that neurotensin (NT) induced translocation of phosphorylated extracellular signal-regulated kinases (ERK-1 and ERK-2) to the ...