1. When pigs were fed diets deficient in pyridoxine or pantothenic acid, ataxia developed and lesions were found in the sensory neuron. 2. The morphological pattern of the lesions differed in the early stages of the two deficient states. Degeneration of the peripheral process of the sensory neuron was the initial and most prominent feature in pyridoxine deficiency. Chromatolysis was the first e...

The literature concerning the nutrition of the propionic acid bacteria was reviewed by Thompson (1943). He attempted to determine which of the Propionibacterium species could be grown on synthetic media containing B vitamins and, if growth occurred, to show which vitamins were required. He was able to grow satisfactorily through repeated subculture five out of nine cultures. All five of these c...

The acetylation reaction involving detoxification of various aromatic amines both in vitro and in viva has become of new importance with the discovery by Lipmann et al. (1) that the coenzyme necessary for this coupling contains pantothenic acid. In an earlier paper (2), we gave evidence demonstrating that pantothenic acid is necessary for normal acetylation of p-aminobenzoic acid (PAB) by rats....

I t was first reported in 1939 (1) that hepatic injury, mainly in the form of acute zonal or diffuse necrosis, occurred irregularly in young rats fed a basal diet devoid of vitamin B (casein 18, cane sugar 68, melted butter fat 8, cod liver oil 2, salt mixture 4) and supplemented with thiamine, riboflavin, and pyridoxine. Thus, this ration was still deficient in several other members of the vit...

Coenzyme A (CoA) is a pantothenic acid-derived metabolite essential for many fundamental cellular processes including energy, lipid and amino acid metabolism. Pantothenate kinase (PANK), which catalyses the first step in the conversion of pantothenic acid to CoA, has been associated with a rare neurodegenerative disorder PKAN. However, the consequences of impaired PANK activity are poorly under...