We demonstrate for the first time that optical coherence tomography (OCT) imaging can reliably distinguish between morphologic features of low risk pancreatic cysts (i.e., pseudocysts and serous cystadenomas) and high risk pancreatic cysts (i.e., mucinous cystic neoplasms and intraductal papillary mucinous neoplasms). In our study fresh pancreatectomy specimens (66) from patients with cystic le...

Paraovarian cysts are a rare pathology, constituting 10-20% of the adnexal masses. The origin can be represented by paramesonephric ducts (Hydatid cysts of Morgagni), vestiges of mesonephric ducts also represented by mesothelium, or neoplastic (cystadenomas or cystadenofibromas) that are mostly benign. Borderline or malignant paraovarian tumors are encountered less often. This article presents ...

Tuberous sclerosis (TSC) is an autosomal dominant genetic disorder in which benign hamartomas develop in multiple organs, caused by mutations in either TSC1 or TSC2. We developed a murine model of Tsc2 disease using a gene targeting approach. Tsc2-null embryos die at embryonic days 9.5-12.5 from hepatic hypoplasia. Tsc2 heterozygotes display 100% incidence of multiple bilateral renal cystadenom...

OBJECTIVE Approximately 50% of human malignancies present with mutations in p53, which is the most common tumor suppressor gene involved with human malignancies. Bcl-2 is a protooncogene, and expression of its protein product is associated with a better prognosis in several malignancies. Ki-67 is a marker of cellular proliferation. The purpose of this study was to determine whether simultaneous...

Scrotal and inguinal masses are common patient complaints that prove diagnostically challenging due to the multiple anatomic structures found in the confined space of the scrotum. History and adequate examination is the cornerstone in diagnosing scrotal pathology. Ultrasonography is the principle radiologic study used to evaluate scrotal masses. This can locate the site of a mass, and different...

BACKGROUND Most cystic neoplasms of the pancreas (CNPs) are incidentally discovered. Their management continues to be debated and preoperative diagnosis is often inaccurate. METHODS Retrospective review of 330 patients with incidentally discovered CNPs. Preoperative and final histological diagnoses were correlated. RESULTS 41% (136/330) of patients were operated on at diagnosis. 50 patients...

The Medical Journal of Australia ISSN: 0025729X 3 January 2011 194 1 44-45 ©The Medical Journal of Australia 2011 www.mja.com.au Lessons from Practice one in 36 000 live births. The VHL gene is involved the transcription of vascular endothelial growth fa platelet-derived growth factor (PDGF) and other h cible proteins. Inactivation promotes tumour ang growth through overexpression of VEGF and P...