BACKGROUND Paraoxonase is an HDL-associated enzyme that protects lipoproteins from oxidative modifications. Smoking is a major cardiovascular risk factor that promotes lipid peroxidation. Cigarette smoke has been shown in vitro to inhibit paraoxonase. The present study examined the hypothesis that smoking is associated with modulated serum activities and concentrations of paraoxonase. METHODS...

objective: the aim of this study was to investigate the effect of pomegranate juice (pj) on the paraoxonase and arylesterase activity of human serum paraoxonase( pon1). material and method: fifty patients with type 2 diabetes mellitus consumed 200 ml of pj daily for a period of 6 weeks. blood was collected from the patients before and after pj consumption after 12 h of fasting. blood sugar, tot...

There are many evidences that human serum paraoxonase activity modifies plasma lipid profile and paraoxonase has an antiatherogenic property. Non-selective beta-blockers affect plasma lipid profile too, but they have atherogenic property when patients take these drugs in long term. In this study the effect of propranolol, a non-selective beta-blocker, on paraoxonase activity was investigated. L...