OBJECTIVE To determine whether ultraviolet B phototherapy at home is equally safe and equally effective as ultraviolet B phototherapy in an outpatient setting for patients with psoriasis. DESIGN Pragmatic multicentre single blind randomised clinical trial (PLUTO study). SETTING Dermatology departments of 14 hospitals in the Netherlands. PARTICIPANTS 196 patients with psoriasis who were cl...

Objective: The aim of this study is to assess the neutrophil lymphocyte ratio (NLR) as an inflammatory marker in patients with psoriasis and to compare it with healthy subjects and to evaluate the correlation with the severity of the disease. Methods: 104 psoriasis patients and 70 healthy persons were included as the control group. The laboratory results were recorded retrospectively from the p...

Psoriasis is an autoimmune disease that characterized by the appearance of lesions on skin. The current treatment aims to control symptoms. efficacy Stachytarpheta jamaicensis (L.) Vahl’s for rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. aim this research was evaluate effect water extract S. leaves psoriasis model (male Balb/c mice) induced topically im...

chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. ...

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokin...

BACKGROUND Briakinumab is a monoclonal antibody against the p40 molecule shared by interleukin-12 and interleukin-23, which is overexpressed in psoriatic skin lesions. We assessed the efficacy and safety of briakinumab as compared with methotrexate in patients with psoriasis. METHODS In this 52-week trial, we randomly assigned 317 patients with moderate-to-severe psoriasis to briakinumab, at ...

Apremilast, an oral, small-molecule phosphodiesterase 4 inhibitor, works intracellularly within immune cells to regulate inflammatory mediators. This phase 2b randomized, placebo-controlled study evaluated efficacy and safety of apremilast among Japanese patients with moderate to severe plaque psoriasis. In total, 254 patients were randomized to placebo, apremilast 20 mg b.i.d. (apremilast 20) ...

The “Psoriasis Area and Severity Index (PASI)” is commonly used to measure the severity of psoriasis at a specific point in time. This score does not consider patient history, leaving possible gap satisfaction patients regarding their care. cross-sectional study aimed test if PeakPASI, highest PASI ever measured, beneficial additional tool assess long-term burden, variations treatments comorbid...

OBJECTIVE In this study, we aimed to investigate atrial electromechanical delay (EMD) in patients with psoriasis. SUBJECTS AND METHODS A total of 43 patients with psoriasis (26 mild-moderate, 17 severe) and 17 healthy control subjects were enrolled. Patients with psoriasis were divided into two groups: the mild-moderate group and the severe group according to their psoriasis area severity ind...