With a view to examine the effect of chronic maternal stress on cognitive function in the offspring during young age, pregnant Wistar rats were subjected to restraint stress from embryonic day 11 till delivery. Male and female pups born to these stressed rats were subjected to passive avoidance test on postnatal day 30 and 31. Results were compared with rats of the same age and sex born to cont...

Temporal lobe epilepsy (TLE) is a disorder of the central nervous system in which hippocampus is mostly involved and causes memory impairment. Kindling is a model of inducing epilepsy which is created through pentylenetetrazol (PTZ) administration. This study examines the role of the aqueous extract of Boswellia on the learning and development of brain (formation of dendritic branches and axons...

MALIN, D. H. Synthetic scotophobin: analysis of behavioral effects on mice. PHARMAC. BIoCHEM. BEHAV. 2(2) 147-153, 1974. Scotophobin is a peptide previously identified [ 141 as the behaviorally active factor in brain extract of rats trained in passive dark avoidance. Mice injected intraperitoneally with a synthetic version of scotophobin or placebo were tested without reinforcement in a box wit...

BACKGROUND It has been reported that epilepsy is a disorder of the central nervous system that causes memory impairment. This study examines the role of the aqueous extract of Boswellia on the learning disability of the pentylenetetrazol (PTZ)-induced kindled rats. METHODS In this experimental study, 64 male rats were used. Kindling seizures were induced by three injections of 25 mg/kg of PTZ...

Nerve growth factor (NGF) has been shown to improve damage in spatial cognition following aging, whereas epidermal growth factor (EGF) is important in brain cell proliferation. It is also known that the adult mammalian central nervous system contains persistent progenitor cells with characteristics of stem cells. These studies suggest that under appropriate external stimuli progenitor cells may...

BACKGROUND Rats receive information from other conspecifics by observation or other types of social interaction. Such social interaction may contribute to the effective adaptation to changes of environment such as situational switching. Learning to avoid dangerous places or objects rapidly occurs with even a single conditioning session, and the conditioned memory tends to be sustained over long...

Objectives: The aim of our research is to study the effect dipentylphthalate (DPeP), a plasticizer on cognition and various oxidative stress markers in mice, explore modulatory effects MK-801. Methods: In present study, experimental mice were orally treated with two doses (33 100 mg/kg) DPeP for 28 days. Cognitive functions assessed using spatial navigation task Morris water maze (MWM) step-dow...