The occurrence of various congenital anomalies, including heart defects, in children whose mothers had suffered from rubella during pregnancy was originally described by Gregg (1941) in Australia and these observations have been confirmed by many other workers. There is, however, surprisingly little detailed information available about the particular types of congenital heart defect that may oc...

background: the ductus arteriosus connects the main pulmonary trunk to the descending aorta. the incidence of isolated patent ductus arteriosus (pda) in full-term infants is about 1 in 2000. the amplatzer ductal occluder (ado) is recommended for pdas with sizes larger than 2 mm. in this procedure, we must confirm the ado position in pda by aortogram from the arterial line. the purpose of this s...

Inhibitors of the cyclo-oxygenase component of prostaglandin-H2 synthetase, namely indomethacin and ibuprofen, are commonly used in the treatment of hemodynamically significant patent ductus arteriosus. These drugs are associated with serious adverse events, including gastrointestinal perforation, renal failure and bleeding. The role of paracetamol, an inhibitor of the peroxidase component of p...

T HE most frequent cardiovascular anomaly following maternal rubella is patent ductus arteriosus.1-0; The majority of patients with typical signs of patent ductus arteriosus are treated surgically without special diagnostic studies such as cardiac catheterization and angiocardiography. In these individuals residual systolic murmurs may persist and are often attributed to mild pulmonary valvular...

Surgical closure of patent ductus arteriosus in adults involves a number of risks because there are associated anatomic and histologic alterations. Between October 1992 and August 2008, 23 patients were referred to our department with isolated patent ductus arteriosus. Their age ranged from 16-75 years (median 25.5 years) and their weight from 52-80 kg (median 57 kg). The pulmonary diameter ran...

Data on the natural history of infants discharged with patent ductus arteriosus is sparse. We report on the 36-months follow-up after hospitalization in 68 infants discharged with an open ductus arteriosus. Notwithstanding a high spontaneous closure rate, catheter intervention in 5 infants illustrates a critical need for cardiologic follow-up.

The management of patent ductus arteriosus in the preterm infant is one of the areas of clinical care that is subjected to great practice variation. This is sadly one of the consequences of widespread adoption of closure of the patent ductus arteriosus by pharmacological or surgical means without subjecting the treatment approaches to rigorous randomized control trials. The diverse approaches t...

BACKGROUND Early fluid and electrolyte imbalances may be associated with an increased risk of bronchopulmonary dysplasia. OBJECTIVE We sought to establish an association between fluid and electrolyte balance in the first week of life and the risk of bronchopulmonary dysplasia. METHODS Clinical charts of 205 neonates <32 weeks gestational age and/or <1,250 g birth weight (admitted to our NIC...