Resonance Raman optical activity (RROA) possesses all aspects of a sensitive tool for molecular detection, but its measurement remains challenging. We demonstrate that reliable recording RROA chiral colorful compounds is possible, only after considering the effect electronic circular dichroism (ECD) on ROA spectra induced by dissolved compound. show number model vitamin B12 derivatives are chem...

Spectral imaging requires rapid analysis of spectra associated with each pixel. A rapid algorithm has been developed that uses iterative matrix inversions to solve for the absorption spectra of a tissue using a lookup table for photon pathlength based on numerical simulations. The algorithm uses tissue water content as an internal standard to specify the strength of optical scattering. An exper...

Abstract. We present a detailed study of left-right-imbalance measures for random binary search trees under the random permutation model, i.e., where binary search trees are generated by random permutations of {1, 2, . . . , n}. For random binary search trees of size n we study (i) the difference between the left and the right depth of a randomly chosen node, (ii) the difference between the lef...

A concise theoretical treatment is developed for the calculation of mean time, differential pathlength, phase shift, modulation depth and integrated intensity of measurements of light intensity as a function of time on the surface of tissue, resulting from either the input of picosecond light pulses, or radio frequency-modulated light. The treatment uses the Green's function of the diffusion ap...

We have implemented a photothermal absorbance strategy where optical absorbance induced solvent temperature increases are monitored using electrolyte conductivity. This method produces a response that is independent of pathlength, assuming thermal conductivity issues can be neglected, and has been suggested to be an interesting approach for use in capillary-based systems, but sensitivity was fo...

We present the enabling concept and technology for a dual spacecraft formation-flying optical interferometer, to be launched into a deep space orbit as Space Technology 3. The combiner spacecraft makes use of a nested cat’s eye delay line configuration that minimizes wavefront distortion and stores 20 m of optical pathlength in a package of ∼ 1.5 m length. A parabolic trajectory for the seconda...

A thermostatted reaction cuvet, operating under computerized or manual temperature control in the ultraviolet or visible region, is described and evaluated. The cell was designed for use with the automated chemistry system described earlier [Clin. Chem. 19, 1114 (1973)], but can readily be adapted for other applications. The entire 3-ml cuvet assembly warms from ambient temperature to 37 degree...