The rapid rise of antibiotic resistance has renewed interest in phage therapy - the use of bacteria-specific viruses (phages) to treat bacterial infections. Even though phages are often pathogen-specific, little is known about the efficiency and eco-evolutionary outcomes of phage therapy in polymicrobial infections. We studied this experimentally by exposing both quorum-sensing (QS) signalling ...

Today, childhood caries is main health related disease it affects many schooling children in countries especially developed by lactic acid bacteria. So this present the isolating 50 bacteria from different decay affected children’s Fen Dental Clinic, Tirupur Dt. The emerging LAB confirmed phenotype and genotype characterization. After, pathogen screened for production of biofilm to check resist...

A ruptured bacteria-containing organelle within the cytosol of an infected eukaryotic cell frequently initiates host defense responses that restrict pathogen replication. Therefore, source for lipids must be found to accommodate the organelle membrane expansion required to support bacterial replication. How host cells are manipulated to provide lipids for the expansion of pathogen-occupied orga...

Alzheimer’s disease (AD) is the most common neurodegenerative disease, which characterized by deposition of senile plaques composed amyloid-β (Aβ) and neurofibrillary tangles (NFTs) hyperphosphorylated tau. Currently, underlying cellular molecular mechanisms AD are still unclear. Growing evidence suggests that pathogen infections prominently promote development pathology. In this article, we re...

The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer membrane that plays a key role in host-pathogen interactions with the innate immune system. During infection, bacteria are exposed to a host environment that is typically dominated by inflammatory cells and soluble factors, including antibiotics, which provide cues about regulation of gene expression. Bacteri...

Ubiquitylation is one of the cardinal post-translational modifications in the cell, balancing several distinct biological processes and acting as a pathogen recognition receptor during bacterial pathogen invasion. A dense layer of polyubiquitin chains marks invading bacteria that gain access to the host cytosol for their selective clearance via xenophagy. However, the enzymes that mediate recog...