The filamentous fungus Aspergillus clavatus is known to produce a variety of secondary metabolites (SM) such as patulin, pseurotin A, and cytochalasin E. In fungi, the production of most SM is strongly influenced by environmental factors and nutrients. Furthermore, it has been shown that the regulation of SM gene clusters is largely based on modulation of a chromatin structure. Communication be...

In 1942 Wiesner (1) and Waksman, Horning, and Spencer (2) demonstrated that filtrates from cultures of Aspergillus clavatus grown upon synthetic media possess antibiotic activity. These investigators extracted and partially purified the active material (which was named clavacin by Waksman) but did not report its isolation in pure form. As a result of the observations made by Waksman’s group, pa...

(+)-Isoepoxydon has been established as the major causative agent of interference competition between Poronia punctata (NRRL 6457), a late fungal colonist of cattle dung, and two early-occurring dung colonists, Ascobolus furfuraceus (NRRL 6460) and Sordaria fimicola (NRRL 6459). This compound was isolated from ethyl acetate extracts of liquid cultures of P. punctata by silica gel chromatography...

Penicillium expansum isolated from meat and apples produced both patulin and citrinin. Toxin identity was confirmed by spectroscopic and physical methods. The mean lethal dose in chicken embryos was determined for toxins administered both singly and in various ratios. Data from simultaneous administration of mycotoxin combinations plotted as isobolograms showed and additive effect. Both toxins ...

This study identified secondary metabolites produced by Alternaria alternata, Colletotrichum gloeosporioides, and Penicillium digitatum in fruits of two blood orange cultivars before harvest. Analysis was performed UHPLC–Q-TOF-MS. Three types were selected, asymptomatic, symptomatic showing necrotic lesions caused hail, mummified. Extracts from peel juice analyzed separately. the prevalent spec...