Strategies to optimize alveolar recruitment and prevent lung overinflation are central to ventilatory management of patients with acute lung injury (ALI). The recent description of overinflation using multilinear regression analysis of airway pressure (Paw) and flow (V') data allows a functional assessment of lung mechanics. However, this technique has not been studied in ALI patients. During 1...

STUDY OBJECTIVES To assess the reliability of new and traditional oxygenation measurements in reflecting intrapulmonary shunt. DESIGN Prospective study. SETTING Cardiac surgery unit at a university hospital. PATIENTS Fifty-five patients undergoing coronary artery bypass grafting. MEASUREMENTS AND RESULTS Simultaneous blood samples were collected from an indwelling arterial line and a ca...

Low-temperature atmospheric pressure plasma technology has been used in agriculture and plant science by direct indirect treatment of bio-samples. However, the cellular molecular mechanisms affected plasma-activated water (PAW) are largely unexplored. In this study, PAW generated from a surface dielectric barrier discharge (SDBD) device was for development. Physicochemical analysis performed to...

Nitroglycerin (NTG) has recently been suggested to decrease myocardial ischemia and enhance cardiac pump function during acute myocardial infarction (AMI). To evaluate the sublingual agnet in this condition, the hemodynamic effects of 0.4 mg NTG administered to 16 supine patients during the first 72 hours of AMI were determined serially 5, 10 to 15, and 20 to 30 minutes post-NTG. Data were eval...

The milky white latex of plant Calotropis procera produces inflammation of the skin and mucous membranes on accidental exposure. It produces edema on local administration due to the release of histamine and prostaglandins and is associated with hyperalgesia. In the present study we have evaluated the antiedematous and analgesic activity of antiinflammatory drugs against inflammatory response in...

Atmospheric-pressure non-thermal bio-compatible plasma is a partially ionized gas with electrically charged particles. Previous studies demonstrated that dielectric barrier discharge (DBD) plasma could induce apoptosis of various cancer cells, in particular demonstrating the selective cytotoxicity of cancer cells over normal cells. Therefore, DBD plasma can be considered as a potential cancer t...

Left-right direction of paw usage in the mouse depends on the genotype and the directional nature of the test. There are two phenotypic classes; in some strains, direction of paw usage is learned or conditioned by the direction of the initial test chamber and the experience of reaching and, in other strains, paw usage is a constitutive behaviour not affected by previous experience. We report th...

BACKGROUND Selection of the PEEP associated with the best compliance of the respiratory system during decremental PEEP titration can be used for the treatment of patients suffering from ARDS. We describe changes in transpulmonary pressure (Ptp) and gas exchange during a decremental PEEP titration maneuver in subjects with pulmonary ARDS. METHODS Eleven subjects with early ARDS were included. ...

The aim of this study was to test antinociceptive properties of venlafaxine in rats with carrageenan-induced pain and inflammation. Pain was provoked with carrageenan (1%) injection into the plantar surface of the rat paw-pad. The effect of venlafaxine on carrageenan-induced mechanical hypersensitivity, mechanical stimulation response (the von Frey monofilament test) as well as the size of carr...

Background: Teucrium stocksianum (T. stocksianum) is one of the important members of the genus Teucrium which contains numerous biologically active compounds. Traditionally, it is used for the treatment of fever, pain, as expectorant and blood purifier. Researchers are trying to discover plants origin, novel and safe remedies for the management of various ailments. The present study was aimed t...