The parabrachial and adjacent Kölliker-Fuse (PBN/KF) nuclei play a key role in relaying visceral afferent inputs to the hypothalamus and limbic system and are, thus, believed to participate in generating nausea and affective responses elicited by gastrointestinal (GI) signals. In addition, the PBN/KF region receives inputs from the vestibular system and likely mediates the malaise associated wi...

Electron paramagnetic resonance (EPR) spectroscopy was used to investigate whether (i) the free radicals produced in the "stunned" myocardium (myocardium with postischemic contractile dysfunction) are derived from O2, (ii) inhibition of radical reactions improves function, and (iii) i.v. spin traps are effective. Open-chest dogs undergoing a 15-min coronary occlusion received an i.v. infusion o...

This paper describes a parallel implementation of a texture segmentation algorithm. The algorithm uses a Pearl Bayes Network (PBN) to combine evidence for the location of urban regions in airborne infra-red linescan images and for the location of driveable regions in autonomous land vehicle imagery. A multilevel PBN approach is introduced and followed by an example which is used to illustrate t...

MOTIVATION Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied in the framework of a probabilistic Boolean network (PBN), which is essentially a finite collection of Boolean networks in which at any discrete time point the gene state vector transitions according to the rul...

We present ASSA-PBN, a tool for approximate steady-state analysis of large probabilistic Boolean networks (PBNs). ASSA-PBN contains a constructor, a simulator, and an analyser which can approximately compute the steadystate probabilities of PBNs. For large PBNs, such approximate analysis is the only viable way to study their long-run behaviours. Experiments show that ASSAPBN can handle large PB...

In dual-carrier (DC)-paired fiber optic long-reach transmission, which extends a point-to-multipoint coherent system to cascaded reconfigurable optical add-drop multiplexing (ROADM) system, narrow passband causes severe performance degradation of the edge subcarriers. this study, we proposed two-dimensional frequency and polarization domain coding multicarrier-frequency control for ROADM filter...

The transmission of visual information from the retina to the visual cortex through the lateral geniculate nucleus (LGN) is a complex process, which involves several neuronal mechanisms, elements, and circuits. The authors investigated this process in anesthetized, paralyzed cats by recording from LGN relay neurons, together with their retinal input, which appeared as slow (S) potentials. The m...

Boolean Network (BN) and its extension Probabilistic Boolean network (PBN) have received much attention in modeling genetic regulatory networks. In this paper, we consider the problem of constructing a PBN from a given positive stationary distribution. The problem can be divided into two subproblems: Construction of a PBN from a given sparse transition probability matrix and construction of a s...

We present a major new release of ASSA-PBN, a software tool for modelling, simulation, and analysis of probabilistic Boolean networks (PBNs). PBNs are a widely used computational framework for modelling biological systems. The steady-state dynamics of a PBN is of special interest and obtaining it poses a significant challenge due to the state space explosion problem which often arises in the ca...

One of the central issues in credit risk measurement and management is modeling and predicting correlated defaults. In this paper we introduce a novel model to investigate the relationship between correlated defaults of different industrial sectors and business cycles as well as the impacts of business cycles on modeling and predicting correlated defaults using the Probabilistic Boolean Network...