Primary cutaneous lymphomas are extranodal non-Hodgkin of T- or B- cell origin, that predominantly affect older patients but have been reported in all age groups and as early the first years life. Diagnosis is challenging requires high clinical suspicion close collaboration between dermatologists, pediatric oncologists pathologists. Skin involvement children adolescents can either be primary se...

Purpose To report a case of a pediatric patient diagnosed with conjunctival lymphoma associated with oral carbamazepine use. Observation An 11-year-old boy who presented with 5-month history of a small nasal conjunctival mass in the left eye that failed therapy with topical corticosteroids. Upon excision and molecular analysis, diagnosis of Follicular Lymphoma was favored. The patient was hea...

Introduction. Burkitt’s lymphoma is a malignant tumor of lymphatic system that originates from B lymphocytes in germinal center of lymph nodes. There may be different clinical types of Burkitt’s lymphoma. Clinical manifestation of disease can involve different localization. Aim. The aim of the study is to present a rare case of a 4.5-year-old patient With Burkitt’s lymphoma of craniofacial loca...

The 3 most common cancers in children in the United States include leukemia (33%), brain tumors (20%), and non-Hodgkin lymphoma (10%). Non-Hodgkin lymphoma in children most commonly manifests in the abdomen (35%), anterior mediastinum (26%), and peripheral lymph nodes (19%). Less than 5% of such cases occur initially in the orbit. In a review of 250 pediatric orbital tumors, Shields and coworke...

Mucosa-Associated Lymphoid Tissue (MALT) lymphoma also referred to as extranodal marginal zone B-cell lymphoma, is rare in the oral soft tissue [1-8]. Primary MALT lymphomas are most commonly seen in the gastrointestinal tract [1,2,4]. Within the oral soft tissue, the salivary glands are the most affected with the parotid gland being the most common site [9] and the minor salivary glands being ...

Assay of cell-free DNA in blood offers an approach to assessment of tumor DNA. We sought to determine whether Epstein-Barr virus (EBV) DNA in cell-free blood is also a good surrogate for the presence of tumor DNA in children with Hodgkin lymphoma, as it is in adults, and whether it correlates with pediatric outcomes. Pediatric patients enrolled in a Children's Oncology Group trial (AHOD0031) we...

We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp....

Primary central nervous system lymphoma (PCNSL) is a rare disease in pediatric age group. A thirteen-year-old male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopath...

Pure infra-diaphragmatic presentation is rare in pediatric Hodgkin lymphoma (HL). Isolated pelvic presentation is restricted to case reports in adults. We describe a unique presentation of HL as a primary pelvic disease in an 11-year-old prepubertal girl. She was treated based on the Euronet-Paediatric Hodgkin's Lymphoma Group protocol (EuroNet-PHL-C1) recommendations and assigned to treatment ...