Introduction: Glioblastoma multiforme (GBM) is the most frequent primary malignant tumor of the brain. But, the treatment of GBM is one of the most problems in cancer therapy because of poor drug penetration across the blood-brain barrier (BBB). Targeting drug delivery system and conjugating targeting moieties was recognized to overcome the poor penetration of chemotherapy drug...

Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological activity in such inhalation formulations. Here salmon calcitonin (sCT) was co-spray dried with linear or branched PEG (L-PEG and B-PEG) and PVP in order to formulate aeros...

background: l-menthol [(1r,3r,4s)-(-)-menthol] is a flavoring that is the main component of mint herb essential oils, especially of the mentha piperita and mentha arvensis species. its low solubility in aqueous systems makes precise formulation necessary in the final products. of the methods available for fabrication of nanoparticles for use in pharmaceuticals, electrospraying is easy and requi...

Monomeric prolactin estimate (MRRL) post polyethylene glycol (PEG) precipitation has been added to the RCPAQAP endocrine program in 2022. The noted flagged low performance compared consensus prompted further investigation identify causes. Prolactin testing by Abbott alinity method showed acceptable excluding any analytical issue with assay. PEG preparation procedure was reviewed and confirmed b...

GOALS To test the hypothesis that the use of a low-residue breakfast (LRB) the day prior to colonoscopy was not inferior to consuming clear fluids alone (CFD) in patients undergoing outpatient colonoscopy with a polyethylene glycol (PEG) bowel preparation. BACKGROUND Optimal colon cleansing is essential for complete visualisation of the mucosa during colonoscopy. Few studies have examined the...

Soluble polymer-supported chemistry is a technology that allows the blending of the benefits of polymer-supported synthesis and solution-phase chemistry. Herein, we describe our recent efforts in this area targeted at exploring the scope of poly(ethylene glycol) (PEG) as the matrix. Specifically we describe the use of PEG as a support for triphenyl phosphine and for the Stille reaction.

Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted fo...

Poly(ethylene glycol) (PEG) is a linear polymer with a wide range of applications in chemical manufacturing, drug development and nanotechnology. PEG derivatives are being increasingly used to covalently modify small molecule and peptide drugs, as well as bioactive nanomaterials in order to improve solubility in biological serum, reduce immunogenicity, and enhance pharmacokinetic profiles. Here...

The famous Towers of Hanoi puzzle consists of 3 pegs (A, B, C) on one of which (A) are stacked n rings of different sizes, each ring resting on a larger ring. The objective is to move the n rings one by one until they are all stacked on another peg (B) in such a way that no ring is ever placed on a smaller ring; the other peg (C) can be used as workspace. The problem has tong been a favourite i...

ZnO/ PEG Nanocomposite material is synthesized by laser ablation of pure Zn target in the mix solution of PEG and of water in different compositions. Synthesized Nanocomposite materials are characterized by using UV-visible absorption, Transmission electron microscope (TEM) and Photoluminescence (PL) spectroscopic techniques. TEM investigation illustrates synthesis of few 2-5 nm quantum dots wi...