نتایج جستجو برای: pentylenetetrazol
تعداد نتایج: 544 فیلتر نتایج به سال:
Background & Aims: Epilepsy is a central nervous system disorder that appears as sudden convulsions, and transient, repetitive and unpredictable movment, with sensory-motor and autonomic sources. Nowadays, patients with epilepsy use various types of chemical drugs which turn out side effects and cause drug resistance in long-term use. Ease of using herbal plants and their public acceptance have...
Background & Aims: Frequent administration of morphine leads to increase in motor activity, motivational properties, and other responses related to this kind of drugs. It has been reported that the impact of morphine on seizure is dose dependent. The aim of this study was to study the impact of chronic exposure to morphine on pentylenetetrazol-induced seizure in rats. Materials & Methods: Neon...
In this communication, the effect of acute treatment with lamotrigine (LTG) and topiramate (TPM) was investigated on release of the main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-kindled freely moving rats using microdialysis. The results showed that the level of Glu and Asp significantly decreased in the PTZ-kindled e...
Studies of Quantum Dots biodistribution have shown that these nanoparticles accumulate in various organs, including brain parenchyma, possibly causing functional alterations. To investigate its potential neurotoxicity, we administered QDs to young mice and studied their behaviour during the following weeks. Spontaneous locomotor behaviour in the home cage was not significantly altered in treate...
Dark neurons are seen in neurosurgical biopsies, experimental ischemia, hypoglycemia, and epilepsy. This study was aimed to investigate probable damage of amygdala due to pentylenetetrazol (PTZ) induced acute seizures in rat. Male Wistar rats were divided into control, sham, and PTZ groups. EEG recordings were performed before and after the PTZ injection in PTZ group. Dark neuron numbers in amy...
DBA/2J (D2) and C57BL/6J (B6) mice exhibit differential sensitivity to seizures induced by various chemical and physical methods, with D2 mice being relatively sensitive and B6 mice relatively resistant. We conducted studies in mature D2, B6, F1, and F2 intercross mice to investigate behavioral seizure responses to pentylenetetrazol (PTZ) and to map the location of genes that influence this tra...
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