Spreadsheet software is the tool of choice for interactive ad-hoc data management, with adoption by billions of users. However, spreadsheets are not scalable, unlike database systems. On the other hand, database systems, while highly scalable, do not support interactivity as a first-class primitive. We are developing DATASPREAD, to holistically integrate spreadsheets as a frontend interface wit...

Existing proceeding-models for the development of mechatronic systems provide a largely parallel action in the detailed development. This parallel approach is to take place also largely independent of one another in the various disciplines involved. An approach for a new proceeding-model provides a further development of existing models to use for the development of Adaptronic Systems. This app...

This study aims to examine alternative methods of normalization that effectively reflect muscle activity as compared to Maximal Voluntary Contraction (MVC). EMG data recorded from knee flexion-extension muscles in 10 control subjects during the stance phase of the gait cycle were examined by adopting different approaches of normalization: MVC, Mean and Peak Dynamic during gait cycles, (MDM and ...

This work presents an innovative approach to the solid model comparison problem which aims to detect and extract all geometric differences between two successive versions of the same part. The automatic model comparator has been developed to offer a standardized information about solid model evolutions to all engineering teams concurrently involved in the product development process. The compar...

Wide diffusion of methodologies and software relevant to Product Lifecycle Management (PLM) in industrial companies faces heterogeneity of IT systems. Especially, the lack of interoperability between Product Data Management (PDM) systems, that drive virtual product development, and Enterprise Resource Planning (ERP), which manages real product, cannot lead to a coherent description of the produ...

In this research paper we address the importance of Product Data Management (PDM) with respect to its contributions in industry. Moreover we also present some currently available major challenges to PDM communities and targeting some of these challenges we present an approach i.e. I-SOAS, and briefly discuss how this approach can be helpful in solving the PDM community’s faced problems. Further...

Engineering processes are increasingly performed in teams by different distributed people including suppliers or external service providers. The engineering tasks are supported by a variety of IT tools like CAD, CAE, office or PDM systems. However these IT applications do not offer any assistance in documenting the engineering processes with all their complex background information like decisio...

Recently, we identified a novel phosphodiesterase 10A (PDE10A) inhibitor, PDM-042 ((E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine). PDM-042 showed potent inhibitory activities for human and rat PDE10A with IC 50 values of less than 1 nmol/L and more than 1000-fold selectivity against other phosphodiesterases. Tritiated PDM-042, [...

We address the parallelization and distributed execution of an algorithm from the area of symbolic computation: propositional satisfiability (SAT) checking with dynamic learning. Our parallel programming models are strict multithreading for the core SAT checking procedure, complemented by mobile agents realizing a distributed dynamic learning process. Individual threads treat dynamically create...