BACKGROUND/OBJECTIVE A high prevalence of Helicobacter pylori infection has been reported in Iran. Although the importance of H. pylori in the induction of peptic ulcer disease is clearly defined, only few studies have addressed its role in bleeding from peptic ulcers. We evaluated the role of H. pylori in peptic ulcer bleeding. METHODS Patients with acute peptic ulcer bleeding (PUB) and thos...

Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...

Background: Refractory peptic ulcers are in the stomach or duodenum that do not heal after eight to twelve weeks of medical/surgical treatment those associated with complications despite medical tssreatment. We herein present a case 44 year old man recurrent perforated duodenal ulcer requiring emergent surgical intervention.

This paper records a study of 400 patients admitted for haematemesis and melaena. Emergency surgery was undertaken on selected patients but the overall mortality increased when more frequent emergency operations were performed in the latter half of the series.

INTRODUCTION Proton pump inhibitors, which are widely used as acid-inhibitory agents for the treatment of peptic ulcers, are mainly metabolized by 2C19 isoenzyme of cytochrome P450 (CYP2C19). CYP2C19 has genetic polymorphisms, associated with extensive, poor, intermediate or ultra-rapid metabolism of proton pump inhibitors. Genetic polymorphisms of CYP2C19 could be of clinical concern in the tr...

The direct urease test was used in 462 patients with normal upper digestive tracts, 108 with duodenal ulcers and 43 with gastric ulcers who attended for upper digestive endoscopy in a prospective study. There was a strong association between Helicobacter pylori infection and current cigarette smoking in patients with normal endoscopy (49.6% vs 35.5%, P < 0.01). The associations of peptic ulcer ...

The proper management of haematemesis and melaena is a constantly recurring problem. Our material consists of 473 patients admitted for haematemesis and melaena between January, 1953, and July, 1958. Four hundred of these (87%) were for proved or suspected peptic ulceration, and the main object of this paper is to discuss the place of surgery in this group. The overall mortality of the ulcer gr...

Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in se...

Treatment of Helicobacter pylori infection with common antibiotics is typically recommended for several digestive conditions, including peptic ulcers. However, reports of resistant H. pylori isolates are increasing, and unfortunately, these do not respond to currently available therapeutic regimens. We report the case of a 31-year-old woman with two peptic ulcers in the duodenal antrum. An H. p...

SOME years ago the senior author publicly expressed [l] the hypothesis that women with rheumatoid arthritis should, with undue frequency, be married to men with peptic ulcers. The reason given for this speculation was that it seemed likely that the hostility in these marriages [2, 31 would leave unmet the husbands’ needs for emotional support and the wives’ needs for ego support. When in the co...