نتایج جستجو برای: peptidomimetics
تعداد نتایج: 550 فیلتر نتایج به سال:
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of diverse small molecules based around a common macrocyclic peptidomimetic framework, containing structural motifs present in many naturally occurring bioactive compounds. Macrocy...
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of ...
Kenneth E. Neet1, Sidharth Mahapatra2, Hrishikesh M. Mehta3 1Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago 2Department of Pediatrics, School of Medicine, Stanford University, Palo Alto 3Department of Pediatrics, Division of Hematology/Oncology/Stem Cell Transplantation Children’s Memorial Hospita...
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