Topical anesthetics have evolved from a simple solution of cocaine to creams, ointments, gels, liposomal preparations, and to the latest sophisticated patches and peels. Topical anesthetics are essential for performing diagnostic, therapeutic, and cosmetic dermatology procedures. These anesthetics noninvasively deliver anesthesia in locally required areas. In this review, we present an overview...

We have assessed the efficacy of a novel bioadhesive amethocaine patch device, compared to Ametop gel, in a randomized, double-blinded trial. Patch and gel formulations, including placebos, were applied to the forearms of volunteers (n = 30) for 40 min. Once the formulations were removed from the skin, anaesthesia was assessed by volunteers using a conventional pinprick test. Pain scores were r...

This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN). The TMP-ME formulation was optimized in vitro with skin permeation experiments, using a uniform experimental design, guided by a pseudo-ternary phase diagram, in which the TMP skin permeation level and mean particle size were indices. Th...

Soft tissue tumors (STTs) include a range of benign and malignant originating from soft tissues. Transarterial percutaneous therapies are image-guided minimally invasive approaches for managing primary metastatic STTs. The objective this review is to discuss transarterial by examining the current literature, including indications, patient selection, safety, effectiveness. (e.g., bland embolizat...

A novel intracoronary microsyringe system (MicroSyringe) was developed for regulated drug injection into the adventitial space. In this report, the feasibility, safety, and distribution pattern of vascular treatment with this modality were tested in 17 swine by delivering Oregon green-labeled paclitaxel (OGP) and tacrolimus. Coronaries were harvested 0.5-96 hr postinjection and analyzed for dru...

This report summarizes the results of 64 percutaneous catheter drainage of abdominal abscesses and fluid collections in 56 patients. Aspiration and drainage was guided with computed tomography in 34 patients and with ultrasound in 30 patients. Success rate was 90%. Infected collections were successfully drained in 94% and noninfected collections in 72% . Partial success was achieved in two...

b-type natriuretic peptide (bnp) level is known to increase in patients with rheumatic mitral stenosis. in this systematic review, we aimed to discuss the possible association between plasma bnp level and the success rate of percutaneous transvenous mitral commissurotomy. pubmed and scopus databases were searched systematically, using the following key terms: “b-type natriuretic peptide” or “bn...

OBJECTIVE To assess the effect of implementing safety-engineered devices on percutaneous injury epidemiology, specifically on percutaneous injuries associated with a higher risk of blood-borne pathogen exposure. DESIGN Before-and-after intervention trial comparing 3-year preintervention (1998--2000) and 1-year postintervention (2001--2002) periods. Percutaneous injury data have been entered p...

in recent decades, percutaneous endoscopic gastrostomy ( peg), has changed feeding and care of patients who can not feed orally. this outpatient procedure is done in most of the endoscopy wards and provides care, nutrition and medications for these patients outside the hospital. peg has rare complications and significantly reduces the cost of care and treatment .with invention of this procedure...