Three-dimensional (3D) cell culture is a powerful tool to study cell growth under 3D condition. To perform a simple test for anti-cancer drugs in 3D culture, visualization of non-proliferated cells is required. We propose a fluorescent imaging-based assay to analyze cancer cell proliferation in 3D culture. We used a pulse-labeling technique with a photoconvertible fluorescent protein Kaede to i...

BACKGROUND Studies suggest that children with congenital heart defects (CHD) are at risk for adverse intellectual functioning. However, factors related to lower intellectual functioning in this group are largely unknown. This study describes intellectual functioning in children with CHD in relation to severity of the heart defect, the child's age, and the socioeconomic status of the family (SES...

Recent observations that personality traits are related to later-life health and wellbeing have inspired considerable interest in exploring the mechanisms involved. Other factors, such as cognitive ability and education, also show longitudinal influences on health and wellbeing, but it is not yet clear how all these early-life factors together contribute to later-life health and wellbeing. In t...

Understanding how and when cognitive change occurs over the life span is a prerequisite for understanding normal and abnormal development and aging. Most studies of cognitive change are constrained, however, in their ability to detect subtle, but theoretically informative life-span changes, as they rely on either comparing broad age groups or sparse sampling across the age range. Here, we prese...

Nowadays, there is an increasing number of robotic applications that need to act in real three-dimensional (3D) scenarios. In this paper we present a new mobile robotics orientated 3D registration method that improves previous Iterative Closest Points based solutions both in speed and accuracy. As an initial step, we perform a low cost computational method to obtain descriptions for 3D scenes p...

We investigate the utility of 3D facial landmark localisation in addressing the varying pose problem in 3D face recognition. We do not focus on the 3D landmark localisation problem itself, rather, we ask: Given the set of salient landmarks visible at some specific pose, what 3D face recognition performance can we expect, given that statistical training was performed at some other (canonical) po...

Ability to stack separate chips in a single package enables three-dimensional integrated circuits (3D ICs). Heterogeneous 3D ICs provide even better opportunities to reduce the power and increase the performance per unit area. An important issue in designing a heterogeneous 3D IC is reliability. To achieve this, one needs to select the data mapping and processor layout carefully. In this paper,...

In this note we consider the problem of computing the 3D shape of an unknown, arbitrarily shaped scene from multiple color photographs taken at arbitrarily distributed viewpoints using a mobile device. The estimated camera orientation and position in 3D space obtained from publicly available SLAM libraries permits us to perform a 3D reconstruction of the observed objects. We demonstrate that it...

The three-dimensional (3D) analysis of anatomical ultrastructures is extremely important in most fields of biological research. Although it is very difficult to perform 3D image analysis on exact serial sets of ultrathin sections, 3D reconstruction from serial ultrathin sections can generally be used to obtain 3D information. However, this technique can only be applied to small areas of a speci...

In this paper, we propose a novel descriptor for shapes. The proposed descriptor is obtained from 3D spherical harmonics. The inadequacy of 2D spherical harmonics is addressed and the method to obtain 3D spherical harmonics is described. 3D spherical harmonics requires construction of a 3D model which implicitly represents rich features of objects. Spherical harmonics are used to obtain descrip...