Alterations of immune homeostasis in the gut may result in development of inflammatory bowel disease. A five-month-old girl was referred for recurrent respiratory and genitourinary tract infections, sepsis in neonatal period, chronic diarrhea, perianal abscess, rectovaginal fistula, and hyperemic skin lesions. She was born to second-degree consanguineous, healthy parents. Her elder siblings wer...

Anal fistula is part of the spectrum of perianal sepsis. It is a chronic condition that may present de novo or after an acute anorectal abscess. Anal fistula causes a variety of prolonged or intermittent symptoms including pain, discharge, and social embarrassment. The goals of management are to eradicate the fistula and prevent recurrence while maintaining continence. Simple anal fistula may b...

Anorectal abscesses are one of the potentially debilitating diseases among them perianal abscess and ischiorectal common. Lateral spread through conjoint tendon leads to a horseshoe abscess. Surgical treatment is incision drainage. Complications include sepsis, faecal incontinence, fistula in ano. Kshara sutra proved effective for ano, which helps preventing recurrence. Here we report case with...

Background: Fistula in Ano is one disease which easy to diagnose but difficult cure as patients report very late phase of the and it leads problems. Aim this study was determine etiology, clinical presentation, efficacy different surgical approach, early post-operative complications, recurrence rate cases fistula Ano.Methods: Prospective Observational Study conducted Department General Surgery,...

Perianal fistulas can occur to up to one-third of patients with Crohn's disease (CD) leading to significant disabling disease and morbidity. Fistulising perianal CD treatment often necessitates a combined pharmacological and surgical approach. Anti-tumor necrosis factor (anti-TNF) therapy, particularly infliximab, has been shown to be very effective for both perianal and internal fistulising CD...

AIM The purpose of the present study was to examine the possible relation between anorectal carcinoma and infliximab therapy for Crohn's disease. PATIENTS AND METHODS This study reviewed the medical records of patients with perianal Crohn's disease, who have required surgical intervention at the Tohoku University Hospital since May 2002, when infliximab was approved as a remedy for Crohn's di...

Background: It is usual to face complexities in perianal abscesses, fistulas and sinus diseases. Perianal indicates a blind tract the area with discharging opening externally. We selected patients tracts intra-luminal openings (Reverse sinus) without any visible external opening. Treatment policy was altered accordingly.Methods: excluded sinuses openings, fistulas, hemorrhoids, simple fissures ...

While adenocarcinomas have occasionally been reported in perianal fistulae, malignant changes occurring in rectovaginal fistulae are rare, with only a handful of reported cases. We report a 73-year-old woman with Crohn's disease who was diagnosed at an early stage with adenocarcinoma in a rectovaginal fistula. This rare disease poses many diagnostic challenges.

BACKGROUND One of the most challenging conditions in Crohn's disease (CD) patients is the treatment of perianal fistulae. We have recently shown that epithelial-to-mesenchymal transition (EMT) plays a crucial role during CD-fistulae development. Dickkopf-homolog 1 (DKK-1) is known to play a key role during EMT. Here, we investigated a role for DKK-1 in the pathogenesis of CD-associated fistulae...

The patient underwent EUA rectum; no abscess, fissure or fistula was found. Rigid sigmoidoscopy revealed diffuse non-specific redness of the rectal mucosa just beyond the dentate line. Random biopsies were taken. Post operatively the patient continued to experience severe pain and remained incontinent. Pathology showed multiple fragments of rectal mucosa heavily infiltrated by a diffuse and she...