Introduction: Clinicians tend to encounter unfavorable situations in the treatment of teeth with severe attachment loss. Periodontal regeneration has been a successful therapeutic approach treatments that require long-term prognosis improvement. This case shows benefits combined regenerative periodontal therapy patient molar severely compromised by furcation, intrabony defects and loss apex. Ca...

PDLSC-mediated periodontal tissue regeneration is considered a promising method for periodontitis treatment, but the supply of PDLSCs is limited. As a potential alternative, WJCMSCs are readily available; however, there is a lack of evidence proving that WJCMSCs are suitable for periodontal tissue regeneration. In this study, we investigated the characteristics of WJCMSCs and PDLSCs. We found t...

Statins are the group of lipid lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have structure similar to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)reductase and competitively inhibits HMG-CoA reductase, which is the rate-limiting step in the mevalonate pathway, thereby reducing blood cholesterol levels. Statins have potential anti-inflammatory effect. ...

: Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regenera...

More than 30 years have passed since the first successful application of regenerative therapy for treatment of periodontal diseases. Despite being feasible, periodontal regeneration still faces numerous challenges, and complete restoration of structure and function of the diseased periodontium is often considered an unpredictable task. This review highlights developing basic science and technol...

Regeneration of periodontal tissues requires a concerted effort to obtain consistent and predictable results in vivo. The aim of the present study was to test a new family of bioactive polymeric membranes in combination with stem cell therapy for periodontal regeneration. In particular, the novel polyester poly(isosorbide succinate-co-L-lactide) (PisPLLA) was compared with poly(L-lactide) (PLLA...

The successful regeneration of periodontal tissues is dependent, in part, on the ability of cells to reconstitute the mineralized tissues of cementum and bone. The aim of the present study was to characterize regeneration-associated cells in terms of their ability to express mineralized tissue macromolecules. Following guided tissue regeneration, cell cultures were established from regenerating...

The loss of alveolar bone, which is very often a consequence of long-lasting inflammation of dental tissue, usually results in loose teeth and eventually the loss of the affected teeth. Removing the causes of periodontal disease with periodontal treatment can stop further alveolar bone decay, however, the problem remains unsolved of how to fix an affected tooth that has more than half of its ro...

This article reviews general aspects about the epithelial cell rests of Malassez (ERM). The historical and general morphological features of the ERM are briefly described. The embryological derivation of the ERM is presented as an important consideration in understanding the events associated with their origin and possible functional roles within the periodontal ligament. The ultrastructural de...